linkurl:1. New role for non-coding RNA; Some long non-coding RNAs are required for the expression of neighboring protein-coding genes in humans — yet another role the mysterious non-coding transcriptome plays in regulating gene expression.U.A. Ørom et al., linkurl:Cell,; 143:46-58, 2010. Evaluated by Leonie Ringrose, Institute of Molecular Biotechnology; A. Clery, D. Theler, and F. Allain, ETH; J. Abrams, Univ. of Texas Southwestern Medical Center at Dallas; E. Lara-Pezzi and N. Rosenthal, EMBL. linkurl:Free F1000 Evaluation;
E. coli
Image: Wikimedia commons, NIAID
linkurl:2. It takes three to replicate; Using single-molecule fluorescence microscopy, researchers observed for the first time the DNA replication machinery at work in living E. coli cells in real time. The novel technique revealed that DNA replication in the bacterium requires the concerted action of three, and not two (as previously thought), polymerases.R. Reyes-Lamothe et al., linkurl:Science,; 328:498-501, 2010. Evaluated by Martin Marinus, UMass Medical School; Sabine...
linkurl:3. Folding, at atomic-scale; D.E. Shaw, et al., linkurl:Science,; 330:341-6, 2010. Evaluations by Gottfried Otting, Australian National Univ; Torleif Härd, Swedish Univ. of Agricultural Sciences. linkurl:Free F1000 Evaluation; linkurl:4. Tricky proteins targeted; J.M. Kee, et al., linkurl:J Am Chem Soc,; 132:14327-9, 2010. Evaluations by Michael Gelb, Univ. Washington; Derek Macmillan, Macromolecular Chemistry, UK; Michael Pirrung, UC Riverside. linkurl:Free F1000 Evaluation; linkurl:5. Defense mechanism elucidated; R.E. Haurwitz, et al., linkurl:Science,; 329:1355-8, 2010. Evaluations by Rachel Senturia and Feng Guo, UCLA; Jim Maher, Mayo Clinic College of Medicine; Robert Batey, U Colorado at Boulder. linkurl:Free F1000 Evaluation;
Heme group B
Image: Wikimedia commons, Ronk01
linkurl:6. How cells traffic heme; R. Chakravarti, et al., linkurl:PNAS,; 107:18004-9, 2010. Evaluations by David Wink, National Cancer Institute; Jack Lancaster, U Alabama at Birmingham. linkurl:Free F1000 Evaluation; linkurl:7. Keys to splitting chromosomes; R.A. Oliveira et al., linkurl:Nat Cell Bio,; 12:185-92, 2010. Evaluations by Tony Maxwell, John Innes Centre, UK; Gennaro D'Urso, U Miami School of Med; Hanna Windecker and Silke Hauf, Max Planck Society. linkurl:Free F1000 Evaluation;

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