linkurl:1. Cytokines, infection blockers; Patients infected by Candida albicans -- the causative agent of chronic mucocutaneous candidiasis disease (CMCD), an infection of the oral and genital mucosae, skin, and nails -- and possibly Staphylococcus aureus, often have mutations in genes encoding interleukin-17 receptor A (IL-17RA) and IL-17F, suggesting an essential role of these cytokines in protecting against such infections.A. Puel et al., "Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity," linkurl:Science,; 332:65-8, 2011. Evaluated by Dan Conrad, Virginia Commonwealth Univ; Jay Kolls, LSU Health Sciences Cen; Klaus Ley, La Jolla Inst for Allergy & Immunology; Sarah Gaffen, Univ Pitt; Joshua Milner, National Inst of Allergy and Infectious Diseases. linkurl:Free F1000 evaluation; linkurl:2. AMPK structure revealed; Researchers detail the crystal structure of AMP-activated protein kinase (AMPK), which helps regulate cell metabolism and has been implicated in diseases such as type 2 diabetes, obesity and...
B. Xiao et al., "Structure of mammalian AMPK and its regulation by ADP," linkurl:Nature,; 472:230-33, 2011. Evaluated by Chris Marshall and Mitsuhiko Ikura, Ontario Cancer Inst; Eduardo Rial, CSIC; Paul Clarke, Univ Dundee; John Kyriakis, Tufts Med Cen. linkurl:Free F1000 evaluation; linkurl:3. New nano-communication?;
Scanning electron micrographs of B. subtilis
Image: Courtesy of the Ben-Yehuda laboratory
G.P. Dubey and S. Ben-Yehuda, "Intercellular nanotubes mediate bacterial communication," linkurl:Cell,; 144:590-600, 2011. Evaluated by Ramanujam Srinivasan, Mithilesh Mishra and Mohan Balasubramanian, National Univ Singapore; Mélanie Hamon and Pascale Cossart, Institut Pasteur; Fabio Bagnoli and Rino Rappuoli, Novartis; Adrian Mehlitz and Roy Gross, Univ Würzburg. linkurl:Free F1000 evaluation; linkurl:4. A long-term memory chemical; A. Suzuki, et al., "Astrocyte-neuron lactate transport is required for long-term memory formation," linkurl:Cell,; 144:810-23, 2011. Evaluated by James Bamburg, Colo St Univ; David Wolfer, Univ Zurich; Faraz Sultan and David Sweatt, Univ Ala Birmingham; Karl-Peter Giese, King's Coll, UK. linkurl:Free F1000 evaluation; linkurl:5. Selfing RNA?; A. Wochner et al., "Ribozyme-catalyzed transcription of an active ribozyme," linkurl:Science,; 332:209-12, 2011. Evaluated by Yan Xu and Makoto Komiyama, Univ Tokyo; Peter Unrau, Simon Fraser Univ; Niles Lehman, Portland State Univ; Michael Yarus, Univ Colorado at Boulder; William Scott, Univ California at Santa Cruz. linkurl:Free F1000 evaluation; linkurl:6. Molding microtubules; C. elegansJ.S. Akella, et al., "MEC-17 is an alpha-tubulin acetyltransferase," linkurl:Nature,; 467:218-22, 2010. Evaluated by Carl Victor Lundin and Yanmin Yang, Stanford Univ Sch of Med; Mark Winey, Univ Colo; Hong-Wei Wang, Yale Univ. linkurl:Free F1000 evaluation; linkurl:7. Cell division with a twist; J. Guizetti et al., "Cortical constriction during abscission involves helices of ESCRT-III-dependent filaments," linkurl:Science,; 331:1616-20, 2011. Evaluated by Martin Lowe, Univ Manchester; Roger Williams, MRC Laboratory of Molecular Biology; Christopher Janetopoulos, Vanderbilt Univ. linkurl:Free F1000 evaluation;

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