linkurl:1. SWEET proteins found; A new class of proteins, dubbed SWEETs, function as glucose transporters, shuttling sugar molecules out of plant, worm and human cells. In some plants, SWEET proteins are co-opted by bacterial pathogens to deliver nutrition to the invaders.L.Q. Chen et al., linkurl:"Sugar transporters for intercellular exchange and nutrition of pathogens,"; __Nature__, 468:527-32, 2010. Evaluations by Julian Schroeder, UCSD; Akiko Sugio and Saskia Hogenhout, The John Innes Centre, UK; John Patrick, Univ Newcastle, Australia; David Alpers, Wash U Sch of Med; Bruno Stieger, Univ Hosp Zurich; Tapio Palva, Univ Helsinki; H Ekkehard Neuhaus, Univ Kaiserslautern, Germany. linkurl:Free F1000 Evaluation; linkurl:2. Codons boost protein expression; A library of more than 150 synthetic green fluorescent protein genes, inserted into E. coli DNA, showed that changing synonymous codons -- different nucleotide triplets that encode the same amino acid -- can alter protein expression up to 250-fold, likely a result of...
G. Kudla et al., linkurl:"Coding-sequence determinants of gene expression in Escherichia coli,"; __Science__, 324:255-58, 2009. Evaluations by Jonathan R Warner, Albert Einstein Coll of Med; Panayiotis Benos, Univ Pitt; Daniel Dykhuizen, Stony Brook; Jurg Bahler, UCL; Neeraj Dhar and John McKinney, EPFL, Switzerland; Audrey Gasch, Univ Wisc-Madison. linkurl:Free F1000 Evaluation;
Astrocyte with focal adhesion kinases
tagged green

Image: Neurorocker at en.wikipedia
linkurl:3. Focus on focal adhesions; P. Kanchanawong et al., linkurl:"Nanoscale architecture of integrin-based cell adhesions,"; __Nature__, 468:580-84, 2010. Evaluations by Martin Humphries, Univ Manchester; Herbert Schiller and Reinhard Fassler, Max Planck Gesellschaft, Germany; Ronen Zaidel-Bar, Nat Univ Singapore; John Couchman, Univ Copenhagen. linkurl:Free F1000 Evaluation; linkurl:4. The degradation trick; F. Zhang et al., linkurl:"Differential arginylation of actin isoforms is regulated by coding sequence-dependent degradation,"; __Science__, 329:1534-37, 2010. Evaluations by Sarah M P Jacobo and Andrius Kazlauskas, Harvard Med Sch; Jike Cui and Dennis Wall, Harvard Med Sch; Irina Kaverina, Vanderbilt Univ Med Cntr; Zhihua Li and Edward M Marcotte, Univ Texas. linkurl:Free F1000 Evaluation; linkurl:5. Fat rat daddies have diabetic daughters; S.F. Ng et al., linkurl:"Chronic high-fat diet in fathers programs beta-cell dysfunction in female rat offspring,"; __Nature__, 467:963-6, 2010. Evaluations by Russell Bonduriansky, Univ New South Wales, Australia; Enrico Avvedimento, Univ Federico II, Italy; Qingchun Tong and Perry Bickel, Univ Texas; Atsushi Iriki, RIKEN Brain Sci Inst, Japan; Mehboob Hussain, Johns Hopkins Univ; William H Colledge, Univ Cambridge. linkurl:Free F1000 Evaluation; linkurl:6. Shaping the ER; Y. Shibata et al., linkurl:"Mechanisms determining the morphology of the peripheral ER,"; __Cell__, 143:774-88, 2010. Evaluations by Charles Barlowe, Dartmouth Med Sch; Matthias Seedorf, Univ Heidelberg, Germany; Sascha Martens, Univ Vienna. linkurl:Free F1000 Evaluation; linkurl:7. The genome shuffle; P.J. Stephens et al., linkurl:"Massive genomic rearrangement acquired in a single catastrophic event during cancer development,"; __Cell__, 144:27-40, 2011. Evaluations by Jordi Camps and Thomas Ried, NCI/NIH; Yamini Dalal, NCI/NIH; Giovanni Neri, Univ Cattolica del S Cuore, Italy; Robert Booth, Virobay Inc; Yan Xu and Makoto Komiyama, Univ Tokyo. linkurl:Free F1000 Evaluation;

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