linkurl:1. Group invasion; Cancer cells invade en mass when actomyosin is downregulated at cell-cell contacts. Blocking that downregulation by depleting a cell matrix adhesion protein called DDR1 leads to increased actomyosin activity and poor cancer cell migration.C. Hidalgo-Carcedo, et al., "Collective cell migration requires suppression of actomyosin at cell-cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6," linkurl:Nat Cell Bio,; 13:49-58, 2011. Evaluations by Adi Dubash and Kathleen J Green, Northwestern Univ Med School; Roberto Mayor, Univ College London; Martin A Schwartz, Univ of Virginia; Michael Dohn and Albert Reynolds, Vanderbilt University; Richard Klemke, Univ of California, San Diego. linkurl:Free F1000 Evaluation;
Slime mold fruiting body.
Image: Daniel J. Dickinson, Program in Cancer Biology, Stanford University
linkurl:2. Slime mold complexity; simple slime mold may not be as dissimilar from complex multicellular creatures as previously assumed. When the single-celled organisms...
D.J. Dickinson, et al., "A polarized epithelium organized by beta- and alpha-catenin predates cadherin and metazoan origins," linkurl:Science,; 331:1336-9, 2011. Evaluations by Mirna Perez-Moreno, Centro National de Investigaciones Oncologicas; Thomas Egelhoff, Cleveland Clinic Foundation; Barry Denholm, Susan Wan and Helen Skaer, Univ of Cambridge; Jeffrey Williams, Univ of Dundee; Cara Gottardi, Northwestern Univ. linkurl:Free F1000 Evaluation; 3. Neuron migrationE. Pacary, et al., "Proneural transcription factors regulate different steps of cortical neuron migration through Rnd-mediated inhibition of RhoA signaling," linkurl:Neuron,; 69:1069-84, 2011. Evaluations by Isabel Martinez-Garay and Ulrich Mueller, The Scripps Research Institute; Ryann Fame and Jeffrey Macklis, Massachusetts General Hospital. linkurl:Free F1000 Evaluation; 4. Sick scienceP. Lawrence and J. Garwood. "The heart of research is sick," Lab Times, 2:24-31, 2011. Evaluations by Ferdinando Boero, Universita' del Salento; Helen Skaer, Univ of Cambridge. linkurl:Free F1000 Evaluation; 5. Patterning contradiction resolvedCaenorhabditisE. Hoyos, et al., "Quantitative variation in autocrine signaling and pathway crosstalk in the caenorhabditis vulval network," linkurl:Curr Biol,; 12:527-38, 2011. Evaluations by David Fitch, New York Univ; Benjamin Podbilewicz, Technion-Israel Institute of Technology. linkurl:Free F1000 Evaluation; 6. Neural switchH. Li, et al., "Phosphorylation regulates OLIG2 cofactor choice and the motor neuron-oligodendrocyte fate switch," linkurl:Neuron,; 69:918-29, 2011. Evaluations by Danielle Harlow and Wendy Macklin, Lerner Research Institute; Jean-Francois Brunet, Institut de Biologie de l'Ecole normale superieure. linkurl:Free F1000 Evaluation; 7. Maintaining tensionV. Maruthamuthu, et al., "Cell-ECM traction force modulates endogenous tension at cell-cell contacts," linkurl:PNAS,; 108:4708-13, 2011. Evaluations by Ana Tadeu and Valerie Horsley, Yale Univ; Deborah Leckband, Univ of Illinois at Urbana-Champaign. linkurl:Free F1000 Evaluation;

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