linkurl:1. The hidden transcriptome;
A model of RNA
Image: Wikimedia commons
Adding to the picture that long non-coding RNAs (ncRNAs) are essential to gene transcription, researchers identified a handful of ncRNAs that promote the expression of neighboring human genes that code for important regulators of cell development and differentiation.U.A. Orom et al., "Long noncoding RNAs with enhancer-like function in human cells," linkurl:__Cell__,; 143:46-58, 2010. Evaluated by Leonie Ringrose, Inst of Mol BiotechGmbH, Austria; Antoine Clery, Dominik Theler and Frederic Allain ETH, Switzerland; John Abrams, Univ of Texas Southwestern Med Cntr at Dallas; Herbert Steinbeisser Univ Heidelberg, Germany; Enrique Lara-Pezzi and Nadia Rosenthal, The European Molecular Biology Laboratory (EMBL), Italy. linkurl:Free F1000 Evaluation; linkurl:2. iPSCs, hold the retrovirus; main drawback of reprogramming adult somatic cells into induced pluripotent stem cells is that using stably integrated retroviruses to trigger the conversion can coax the resulting stem cells into forming tumors. This...
L. Warren et al., "Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA," linkurl:__Cell Stem Cell__,; 7:618-30, 2010. Evaluated by Rudy Juliano, UNC,Chapel Hill; Beatriz Aranda-Orgilles and Iannis Aifantis HHMI/NYU School of Med; Karen Maass and Glenn Fishman, NYU Langone Med Cntr; Arnold Kriegstein, Univ of Calif. linkurl:Free F1000 Evaluation; M.C. Marchetto et al., "A model for neural development and treatment of rett syndrome using human induced pluripotent stem cells," linkurl:__Cell__,; 143:527-39, 2010. Evaluated by Kevin Huang and Guoping Fan, David Geffen Sch of Med, Univ of Calif; Eugenio Sangiorgi and Giovanni Neri, Univ Cattolica del S Cuore, Italy; Aaron DiAntonio, Wash Univ Med Sch. linkurl:Free F1000 Evaluation; D.H. Ashton et al., "Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling," linkurl:__Dev Cell__,; 19:259-69, 2010. Evaluated by Mariann Bienz, MRC Lab of Mol Bio; David Dominguez-Sola and Jean Gautier, Columbia Univ Med Cntr; Stefan Koch and Asma Nusrat, Emory Univ. linkurl:Free F1000 Evaluation; R. Tomer et al., "Profiling by image registration reveals common origin of annelid mushroom bodies and vertebrate pallium," linkurl:__Cell__,; 142:800-9, 2010. Evaluated by Andy Groves, Baylor Coll of Med; Leonard Maler, Univ Ottawa; Ariel Pani and Christopher Lowe, Stanford Univ. linkurl:Free F1000 Evaluation; M.J. Prigge et al., "__Physcomitrella patens__ auxin-resistant mutants affect conserved elements of an auxin-signaling pathway," linkurl:__Curr Biol__,; 20:1907-12. Evaluated by John Bowman, Monash Univ; Bert De Rybel and Dolf Weijers, Wageningen Univ; Steffen Vanneste and Jiri Friml, Ghent Univ. linkurl:Free F1000 Evaluation; J. Bouvier et al., "Hindbrain interneurons and axon guidance signaling critical for breathing," linkurl:__Nat Neurosci__,; 13:1066-74. Evaluated by Aguan Wei and Jan-Marino Ramirez, Univ of Washington; Jean-Fran?ois Brunet, Centre National de la Recherche Scientifique (CNRS). linkurl:Free F1000 Evaluation;

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