linkurl:1. How Tregs limit inflammation; T-regulatory cells can multiply their numbers by secreting the cytokine interleukin IL-35, which converts the population of T-cells involved in killing (effector T-cells) into regulatory cells that suppress inflammation, providing a new explanation for how inflammation is reeled in after an infection is cleared. L.W. Collison et al., "IL-35-mediated induction of a potent regulatory T cell population," Nat Immunol, 12:1093-101, 2010. Evaluations by Avinash Bhandoola, Univ Penn; Christian Engwerda, Queensland Inst Med Res, Australia; Lieping Chen, Johns Hopkins Univ Sch of Med; David Serreze, The Jackson Lab; Xiaojing Ma, Weill Med Coll of Cornell Univ; Stephen Cobbold, Univ Oxford; Stanley Perlman, Univ Iowa. linkurl:Free F1000 Evaluation;
linkurl:2. Epigenetic thermometer; Eukaryotes, such as yeast and plants, can sense ambient temperatures at the level of their DNA by evicting or incorporating a histone variant called H2A.Z, which is often associated with gene activation.S.V. Kumar and P.A....
linkurl:3. Fat rat daddies have diabetic daughters; S.F. Ng et al., "Chronic high-fat diet in fathers programs beta-cell dysfunction in female rat offspring," Nature, 467:963-6, 2010. Evaluations by Qingchun Tong and Perry Bickel, Univ Texas; Atsushi Iriki, RIKEN Brain Sci Inst, Japan; Mehboob Hussain, Johns Hopkins Univ; William H Colledge, Univ Cambridge. linkurl:Free F1000 Evaluation; linkurl:4. More complex environments = more sex; L. Becks and A.F. Agrawal, "Higher rates of sex evolve in spatially heterogeneous environments," Nature, 468:89-92, 2010. Evaluations by Hanno Seebens and Bernd Blasius, Carl-von-Ossietzky Univ, Germany; Tony D Long, UC Irvine; Richard Frankham, Macquarie Univ, Australia. linkurl:Free F1000 Evaluation; linkurl:5. Jumping genes mold mammal brains; A.R. Muotri et al., "L1 retrotransposition in neurons is modulated by MeCP2," Nature, 468:443-6, 2010. Evaluations by Joachim Messing, Rutgers Univ; Travis Thomson and William Theurkauf, Univ Mass Med Center. linkurl:Free F1000 Evaluation; linkurl:6. A genome architecture map; H. Tanizawa et al., "Mapping of long-range associations throughout the fission yeast genome reveals global genome organization linked to transcriptional regulation," Nucleic Acids Res, 38:8164-77, 2010. Evaluation by Richard Maraia, Nat Inst of Child Health and Human Dev; Jurg Bahler, Univ Coll London. linkurl:Free F1000 Evaluation; linkurl:7. A function for mTORC2; W.J. Oh et al., "mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide," EMBO, 29:3939-51. Evaluations by Jose Mulet and Ramon Serrano, Univ Politecnica de Valencia-CSIC, Spain; Pam Lochhead and Simon Cook, Mol Signalling Lab, UK; Xuemin Wang and Christopher Proud. linkurl:Free F1000 Evaluation;

Interested in reading more?

Become a Member of

Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member?