linkurl:1. Virus amps up parasite disease; When the parasite that causes Leishmaniasis, a skin-ulcer disease transmitted by sandflies, is infected with a virus, it causes a more severe disease than when it is not infected, by triggering inflammatory cytokines in the host that paradoxically promote parasite's spread. A. Ives et al., "Leishmania RNA virus controls the severity of mucocutaneous leishmaniasis," linkurl:__Science,__; 331:775-78, 2011. Evaluated by Jan Rehwinkel and Caetano Reis e Sousa, Cancer Research UK; Breck Duerkop and Lora Hooper, U of Texas Southwestern Med Ctr; Heidi Snider and Abhay Satoskar, Ohio State Univ; Barbara Papadopoulou, Laval Univ, Canada; Jean-Luc Imler, Univ de Strasbourg, France; Christian Engwerda, Queensland Inst of Med Res, Australia. linkurl:Free F1000 Evaluation; linkurl:2. Cytokines, infection blockers;
Three Leishmania amastigotes
Image: Wikimedia
Patients infected by __Candida albicans__ -- the causative agent of chronic mucocutaneous candidiasis disease (CMCD), an infection of the oral and genital mucosae, skin, and...
A. Puel et al., "Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity," linkurl:__Science,__; 332:65-8, 2011. Evaluated by Dan Conrad, Virginia Commonwealth Univ; Jay Kolls, LSU Health Sciences Cen; Klaus Ley, La Jolla Inst for Allergy & Immunology; Sarah Gaffen, Univ Pitt; Joshua Milner, National Inst of Allergy and Infectious Diseases. linkurl:Free F1000 Evaluation; linkurl:3. Virus infects model worm; M.A. Felix et al., "Natural and experimental infection of caenorhabditis nematodes by novel viruses related to nodaviruses," linkurl:__PLoS Biol,__; 9:e1000586, 2011. Evaluated by Benjamin Podbilewicz, Technion- Israel Inst of Tech, Israel; Jean-Luc Imler, Univ de Strasbourg, France; Morris F Maduro, Univ California Riverside. linkurl:Free F1000 Evaluation; linkurl:4. Tracking IL-17; K. Hirota et al., "Fate mapping of IL-17-producing T cells in inflammatory responses," linkurl:__Nat Immunol,__; 12:255-63, 2011. Evaluated by Alain Dessein, INSERM, France; Reiko Horai and Rachel R Caspi, National Eye Inst, NIH; Tzong-Shyuan Tai and I-Cheng Ho, Brigham & Women's Hospital; Oberdan Leo and Muriel Moser, University of Brussels, Belgium; Linda Bradley, Burnham Institute for Medical Research; Dan Conrad, Virginia Commonwealth University. linkurl:Free F1000 Evaluation; linkurl:5. T-regs accelerate metastasis; W. Tan et al., "Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signaling," linkurl:__Nature__; 470:548-53, 2011. Evaluated by Albert Deisseroth, Sidney Kimmel Cancer Ctr; David Richards and Markus Feuerer, German Cancer Res Ctr (DKFZ);| Mark Boothby, Vanderbilt Univ Sch of Med; Lynn Heltemes-Harris and Michael Farrar, U of Minnesota. linkurl:Free F1000 Evaluation; linkurl:6. Support for antibody-producing cells; V.T. Chu et al., "Eosinophils are required for the maintenance of plasma cells in the bone marrow," linkurl:__Nat Immunol,__; 12:151-19, 2011. Evaluated by Dhaya Seshasayee and Flavius Martin, Genentech; Helene Rosenberg, LAD/NIAID/NIH; Naomi Harwood and Facundo Batista, London Res Inst, Cancer Res UK; Marion Espeli and Ken Smith, U of Cambridge, UK; Shinsuke Taki, Shinshu U Grad Sch of Med, Japan. linkurl:Free F1000 Evaluation; linkurl:7. Receptor-snatching; O.S. Qureshi et al., "Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4," linkurl:__Science,__; 332:600-3, 2011. Evaluated by Lieping Chen, Yale Univ Sch of Med; Amnon Altman, La Jolla Inst for Allergy and Immunology; Oberdan Leo and Muriel Moser, U of Brussels, Belgium. linkurl:Free F1000 Evaluation;

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