linkurl:1. Tracking B-cell movement; By applying GFP technology in a new way, authors tracked B-cell maturation in the lymph nodes as the cells move from an area of rapid proliferation to an area where B cells that produce the best antibodies are selected, and back again, and found an essential role of T helper cells in this transition. G.D. Victora et al., "Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter," linkurl:__Cell,__; 143:592-605, 2010. Evaluated by Jacques Deguine and Philippe Bousso, Inst Pasteur, France; Yinan Wang and Deepta Bhattacharya, Washington Univ in St. Louis; Naomi Harwood and Facundo Batista, London Res Inst, Cancer Res UK; Kai-Michael Toellner, Univ Birmingham, UK. linkurl:Free F1000 Evaluation; linkurl:2. Worm infections; The first naturally occurring virus infection in C. elegans provides researchers with a genetically tractable model for studying virus-host interactions, innate immunity and the evolution of small RNA viral defenses.
M.A. F?lix et al., "Natural and experimental infection of caenorhabditis nematodes by novel viruses related to nodaviruses," linkurl:__PLoS Biol,__; 9:e1000586, 2011. Evaluated by Benjamin Podbilewicz, Technion- Israel Inst of Tech, Israel; Jean-Luc Imler, Univ de Strasbourg, France; Morris F Maduro, Univ California Riverside. linkurl:Free F1000 Evaluation; linkurl:3. Immune battle by suicide; E.A.Miao et al., "Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria," linkurl:__Nat Immunol,__; 11:1136-42, 2010. Evaluated by Sun Mi Choi and Jay Kolls, Lousianna State Univ Health Sci Cen; Volker Briken and David Mosser, Univ of Maryland; Jordan Wesolowski and Fabienne Paumet, Jefferson Medical College; Sebastian Winter and Andreas Baumler, Univ of California, Davis; Nobuhiko Kayagaki, Kim Newton and Vishva Dixit, Genentech. linkurl:Free F1000 Evaluation; linkurl:4.Identifying the unknown; M.M. Reddy, et al., "Identification of candidate IgG biomarkers for Alzheimer's disease via combinatorial library screening," linkurl:__Cell,__; 144:132-42, 2011. Evaluated by Angela Vincent, John Radcliffe Hosp, Univ Oxford; Robert Powers, University of Nebraska; Soumitra Ghosh and Kavita Shah, Purdue Univ; Ivan Gerling, Univ Tennessee Health Sci Cen; David Holtzman, Wash Univ School of Med. linkurl:Free F1000 Evaluation; linkurl:5. Mitochondria cause inflammation; Q. Zhang et al., "Circulating mitochondrial DAMPs cause inflammatory responses to injury," linkurl:__Nature,__; 464:104-7, 2010. Evaluated by Ramzi Fattouh and John Brumell, The Hosp for Sick Children, Canada; Robert Sapolsky, Stanford Univ; Tullio Pozzan, Univ of Padova, Italy; Andrew S Neish, Emory Univ Sch Med; Rajarshi Mukherjee and David Criddle, Liverpool Univ, UK; George Hasko, Univ Med and Dentistry of New Jersey. linkurl:Free F1000 Evaluation; linkurl:6. IL-7 jump starts inflammation; M. Pellegrini et al., "IL-7 Engages Multiple Mechanisms to Overcome Chronic Viral Infection and Limit Organ Pathology," linkurl:__Cell,__; 144:601-13, 2011. Evaluated by Raphaelle Parker and Irini Sereti, NIAID; Tobias Boettler and Matthias von Herrath, La Jolla Inst for Allergy and Immunology; Barry Rouse, Univ Tennessee. linkurl:Free F1000 Evaluation; linkurl:7. Basophils not so necessary; C. Ohnmacht et al., "Basophils orchestrate chronic allergic dermatitis and protective immunity against helminths," linkurl:__ Immunity,__; 33(3):364-74, 2010. Evaluated by Avinash Bhandoola, Univ Penn; Luz Garcia-Hernandez, Javier Rangel-Moreno and Troy Randall, Univ Rochester; James Hewitson and Rick Maizels, University of Edinburgh, UK; Richard L Stevens, Brigham and Women's Hospital, Harvard Medical School; Daniel Mucida and Hilde Cheroutre, La Jolla Institute for Allergy & Immunology. linkurl:Free F1000 Evaluation;

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