linkurl:1. Immune response feeds parasite; Salmonella is able to outcompete resident gut microbes by deriving energy from the inflammatory immune response that is supposed to combat the pathogen. S.E. Winter, et al., "Gut inflammation provides a respiratory electron acceptor for Salmonella," linkurl:__Nature,__; 467:426-9, 2010. Evaluated by Matam Vijay-Kumar and Andrew Gewirtz, Emory Univ; David Alpers, Washington Univ School of Med; Alexei Kurakin and Roya Khosravi-Far, Beth Israel Deaconess Med Cen; Michael Hensel, Univ of Osnabruck; Yvonne Sun and Mary O'Riordan, Univ of Michigan Med School; Wolf-Dietrich Hardt, Swiss Federal Inst of Tech; James Moir, Univ of York; Victor Nizet, Univ of California, San Diego. linkurl:Free F1000 Evaluation;
A dendritic cell
Image: Wikimedia/linkurl:__PLoS Pathogens__;
linkurl: 2. How Tregs limit inflammation; T-regulatory cells can multiply their numbers by secreting the cytokine interleukin IL-35, which converts the population of T-cells involved in killing (effector T-cells) into regulatory cells that suppress inflammation, providing a...
L. W. Collison, et al., "IL-35-mediated induction of a potent regulatory T cell population," linkurl:__Nat Immunol,__; 2010. Evaluated by Stephen Cobbold, University of Oxford; Stanley Perlman, University of Iowa. linkurl:Free F1000 Evaluation; linkurl:3. How to tolerate gut bacteria; S. Manicassamy et al., "Activation of beta-catenin in dendritic cells regulates immunity versus tolerance in the intestine," linkurl:__Science,__; 329:849-53, 2010. Evaluated by Arthur Hurwitz, NIH; Caio Fagundes and Mauro Teixeira, Univ Federal De Minas Gerais, Brazil; Kiyoshi Takeda, Osaka Univ, Japan; Jay Berzofsky, Center for Cancer Research, NCI; Barry Rouse, University of Tennessee; Torben Lund, Univ College London, UK. linkurl:Free F1000 Evaluation; linkurl: 4. Antibody defense inside and out; D.L. Mallery et al., "Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21)," linkurl:__PNAS,__; 107;19985-90, 2010 Evaluated by Lutz Walter, German Primate Center, Germany; David Alpers, Washington Univ School of Med; Nathalie Vigneron and Benoit Van den Eynde, Ludwig Inst for Cancer Res, Belgium; Gijs Versteeg and Adolfo Garcia-Sastre, Mount Sinai School of Med; Diana Koch and Nancy Sawtell, Cincinnati Children's Hosp Med Cen. linkurl:Free F1000 Evaluation; linkurl:5. Directed clean-up; B. McDonald et al., "Intravascular danger signals guide neutrophils to sites of sterile inflammation," linkurl:__Science,__; 330:362-6, 2010. Evaluated by William A Muller, Northwestern Univ, Feinberg School of Med; Samantha Wang and Karsten Gronert, Univ of California, Berkeley; Sharon Hyduk and Myron Cybulsky, Toronto Gen Hosp, Canada. linkurl:Free F1000 Evaluation; linkurl:6. Immune battle by suicide; E.A.Miao et al., "Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria," linkurl:__Nat Immunol,__; 11:1136-42, 2010. Evaluated by Volker Briken and David Mosser, Univ of Maryland; Jordan Wesolowski and Fabienne Paumet, Jefferson Medical College; Sebastian Winter and Andreas Baumler, Univ of California, Davis; Nobuhiko Kayagaki, Kim Newton and Vishva Dixit, Genentech. linkurl:Free F1000 Evaluation; linkurl:7. Allergy gets a new look; A.T. Phythian-Adams, et al., "CD11c depletion severely disrupts Th2 induction and development in vivo," linkurl:__J Exp Med,__; 207:2089-96, 2010. Evaluated by Marc A Williams, EPA; Booki Min, Cleveland Clinic Foundation; Eric Denkers, Cornell Univ. linkurl:Free F1000 Evaluation;

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