linkurl:1. Drug helps - not hurts - in serious lung disease;
Doctors have hesitated to give neuromuscular blocking agents to patients with acute respiratory distress syndrome, a life-threatening lung condition, out of fear the drugs could cause muscle weakness. But a clinical trial found patients who took a neuromuscular blocker were more likely than those on a placebo to survive 90 days, and showed no increase in muscle weakness. (Some F1000 Members, however, disagreed, arguing narcotics are more appropriate in these patients.) L. Papazian, et al., "Neuromuscular blockers in early acute respiratory distress syndrome," N Engl J Med, 363:1107-16. 2010. Evaluations by Hallie Prescott and Jim O'Brien, Ohio State Univ Med Cntr; Alexander Benson and Ivor Douglas, Univ of Colorado and Denver Health; Michael Gropper, UCSF; Rob Basner, Columbia Univ College of Physicians and Surgeons; Jacobo Sellares and Antoni Torres, Hosp Clinic de Barcelona; Marcelo Gama de...
2. Skip the surgery?M.B. Leon, et al., "Transcatheter aortic-valve implantation for aortic stenosis in patients who cannot undergo surgery," N Engl J Med, 2010. Evaluations by Alice Jacobs and Zoran Nedeljkovic, Boston Univ School of Med; Jerome Fleg, NHLBI; Saif Anwaruddin and Samir Kapadia, Cleveland Clin; Wolfgang Schoels, Herzzentrum Duisburg; Bernard Iung, Bichat Hosp; Nawwar Al-Attar, Bichat Hosp; Alvaro Alonso and John Paraskos, UMass Med School. linkurl:Free F1000 Evaluation; 3. New source of stem cellsD. Medici, et al., "Conversion of vascular endothelial cells into multipotent stem-like cells," Nat Med, 16:1400-6, 2010. Evaluations by Jason Ho and Suneel Apte, Cleveland Clinic; Frank Zaucke, Inst for Biochem II; Debabrata Patra and Linda Sandell, Washington Univ Med School; Gadi Pelled and Dan Gazit, Hebrew Univ of Jerusalem; Mervin Yoder, Indiana Univ. linkurl:Free F1000 Evaluation; 4. Strong treatment for mild diseaseF. Zannad, et al., "Eplerenone in patients with systolic heart failure and mild symptoms," N Engl J Med., 364:11-21, 2011. Evaluations by Scott MacKenzie and Eleanor Davies, Glasgow Cardiovas Res Cntr; Sunil Kumar and Sripal Bangalore, Brigham & Women's Hosp; Krishna Gaddam and Hector Ventura, Ochsner Clin Foundation; Florencia Halperin and Robert Dluhy, Brigham & Women's Hosp; Mark Cooper, Baker Med Research Inst and Alfred Hosp. linkurl:Free F1000 Evaluation; 5. Surgery on the wrong sideF.L. Cohen, et al., "Wrong-site craniotomy: analysis of 35 cases and systems for prevention," J Neurosurg, 113:461-73, 2010. Evaluations by Zulfiqar Ahmed, Detroit Children's Hosp; Ian Herrick, Univ of Western Ontario; Robert Macdonald, Univ of Toronto. linkurl:Free F1000 Evaluation; 6. Skin straight to blood
Red blood cells
MDougM, linkurl:Wikimedia Commons;
E. Szabo, et al., "Direct conversion of human fibroblasts to multilineage blood progenitors," Nature, 468:521-6, 2010. Evaluations by Rosanna Botta and Anna Migliaccio, Mt Sinai School of Med; Xiaobing Zhang and Tao Cheng, Univ of Pittsburg; Eirini Papapetrou and Michel Sadelain, Memorial Sloan-Kettering Cancer Cntr. linkurl:Free F1000 Evaluation; 7. Notch your average blood cellsC. Delaney et al., "Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution," Nat Med., 16:232-6, 2010. Evaluations by Hector Mayani, Siglo XXI Nat Med Cntr; Bindu Kanathezhath and James Feusner, Children's Hosp Oakland Res Inst; Patricia Benveniste and Juan Carlos Zuniga-Pflucker, Univ of Toronto and Sunnybrook Res Inst; B. G. Solheim, Oslo Univ Hosp. linkurl:Free F1000 Evaluation;

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