linkurl:1. Powerful tension;
Image of mitotic spindle in a human cell:
microtubules in green, chromosomes in blue, and kinetochores in red.
Wikimedia Commons, linkurl:Afunguy;
Tension stabilizes the attachment of microtubules to kinetochores during cell division in budding yeast, demonstrating how mechanical forces can modulate chromosome movement during replication.B. Akiyoshi, et al., linkurl:"Tension directly stabilizes reconstituted kinetochore-microtubule attachments,";,f1000m Nature, 468:576-9. 2010. Evaluations by Raquel Oliveira, Univ of Oxford; Yamini Dalal, NCI; Eugenio Marco and Gaudenz Danuser, Harvard Med School; Jonathan Millar, Univ of Warwick; Iain Cheeseman, MIT. linkurl:Free F1000 Evaluation; linkurl:2. The genome shuffle; some cancers, chromosomes are broken apart and stitched back together, resulting in tens to hundreds of spontaneous genomic rearrangements, contravening the model of slowly accumulating point mutations and more subtle chromosome rearrangements. The process, dubbed "chromothripsis," occurs in at least 2-3 percent of all cancers, across many subtypes, and is present in...
P.J. Stephens et al., linkurl:"Massive genomic rearrangement acquired in a single catastrophic event during cancer development,";,f1000m Cell, 144:27-40, 2011. Evaluations by Jordi Camps and Thomas Ried, NCI/NIH; Yamini Dalal, NCI/NIH; Giovanni Neri, Univ Cattolica del S Cuore, Italy; Robert Booth, Virobay Inc; Yan Xu and Makoto Komiyama, Univ Tokyo. linkurl:Free F1000 Evaluation; 3. Ribosomes at homeF. Brandt, et al., linkurl:"The three-dimensional organization of polyribosomes in intact human cells,";,f1000m Mol Cell, 39:560-9, 2010. Evaluations by Dmitri Ermolenko and George Makhatadze, Rensselaer Polytechnic Institute; Daniel MacDougall, Margaret Elvekrog and Ruben Gonzalez, Columbia Univ; J Robert Hogg and Kathy Collins, Univ pf California at Berkeley. linkurl:Free F1000 Evaluation; 4. Bizarre replication breaks DNAA. Letessier, et al., linkurl:"Cell-type-specific replication initiation programs set fragility of the FRA3B fragile site,";,f1000m Nature, 470:120-3, 2011. Evaluations by Armelle Lengronne and Philippe Pasero, Ins of Human Genetics. linkurl:Free F1000 Evaluation; 5. Meiosis double playK. Zakharyevich, et al., linkurl:"Temporally and biochemically distinct activities of Exo1 during meiosis: double-strand break resection and resolution of double Holliday junctions,";,f1000m Mol Cell, 40:1001-15, 2010. Evaluations by William Holloman, Weill Medical College of Cornell Univ; Ian Hickson, Univ of Copenhagen. linkurl:Free F1000 Evaluation; 6. Chromatin controls T cellsJ.S. Rawlings, et al., linkurl:"Chromatin condensation via the condensin II complex is required for peripheral T-cell quiescence,";,f1000m EMBO, 30:263-76, 2011. Evaluations by Allan Zajac, Univ of Alabama at Birmingham; Pierre Ferrier, Univ de la Mediterranee; Wendy Bickmore, MRC Human Genetics Unit. linkurl:Free F1000 Evaluation; 7. Rad repairZ. Feng, et al., linkurl:"Rad52 inactivation is synthetically lethal with BRCA2 deficiency,";,f1000m Proc Natl Acad Sci, 108:686-91, 2010. Evaluations by Roland Kanaar, Erasmus Med Center; William Holloman, Weill Med College of Cornell Univ. linkurl:Free F1000 Evaluation;

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