linkurl:1. Identifying the unknown; Researchers present a novel method for identifying antibody biomarkers for diseases without known antigens. The technique, which involves searching for antibodies that bind to various synthetic molecules, may prove useful for identifying diagnostic markers in a wide variety of diseases.M.M. Reddy, et al., linkurl:"Identification of candidate IgG biomarkers for Alzheimer's disease via combinatorial library screening,"; __Cell__, 144:132-42, 2011. Evaluated by Angela Vincent, Univ of Oxford, UK; Robert Powers, Univ of Nebraska; Soumitra Ghosh and Kavita Shah, Purdue Univ; Ivan Gerling, Univ Tennessee Health Sci Cen; David Holtzman, Wash Univ School of Med.linkurl:2. A long-term memory chemical;
Image: Ranveig via Wikimedia
During the formation of long-term memories, neurons in the brain must import lactate, which forms when an energy reserve molecule called glycogen is broken down by specialized brain cells known as astrocytes. A. Suzuki, et al., linkurl:"Astrocyte-neuron lactate transport is required for long-term memory...
linkurl:3. Molding microtubules; J.S. Akella, et al., linkurl:"MEC-17 is an alpha-tubulin acetyltransferase,"; __Nature__, 467:218-22, 2010. Evaluated by Carl Victor Lundin and Yanmin Yang, Stanford Univ Sch of Med; Mark Winey, Univ Colo; Hong-Wei Wang, Yale Univ.linkurl:4. A calcium coordinator; C.Y. Park, et al., linkurl:"The CRAC channel activator STIM1 binds and inhibits L-type voltage-gated calcium channels,"; __Science__, 330:101-5, 2010. Evaluated by Laurel Wright and Juan Rivera, Nat Inst Arthritis and Musculoskeletal and Skin Diseases; Claudia S Bauer and Annette Dolphin, UCL; Robert Burgoyne, Univ Liverpool.linkurl:5. The pig-out switch; Y. Aponte, et al., linkurl:"AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training,"; __Nat Neurosci__, 14:351-5, 2011. Evaluated by Heike Munzberg, Pennington Biomed Res Cntr; Terry Davidson, Purdue Univ; Ann Schreihofer, Univ North Texas Hlth Sci Cntr.linkurl:6. Anxiety's home base; K.M. Tye, et al., linkurl:"Amygdala circuitry mediating reversible and bidirectional control of anxiety,"; __Nature__, 471:358-62, 2011. Evaluated by Mazen Kheirbek and Rene Hen, Columbia Univ; Alejandro Schinder, Leloir Inst, Arg.linkurl:"Eyes in a dish"; M. Eiraku, et al., linkurl:"Self-organizing optic-cup morphogenesis in three-dimensional culture,"; __Nature__, 472:51-6, 2011. Evaluated by Juan Martinez-Morales and Paola Bovolenta Univ Autonoma de Madrid, Spain; Vivien Casagrande, Vanderbilt Univ Sch Med.

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