linkurl:1. Epigenetics in mind; body's tendency to silence the expression of one parental allele in favor of the other -- a practice known as genomic imprinting -- is much more widespread in the brain than scientists have believed, according to a new genome-wide study in mice. Surprisingly, more than 1300 genes in the mouse brain appear to exhibit "parent-of-origin" epigenetic effects.
Kessa Ligerro
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C. Gregg, et al., Science, 329:643-8, 2010. Evaluations by Matt E. Carter and Luis de Lecea, Stanford Univ; Joachim Messing, Rutgers Univ; Yoshiho Ikeuchi and Azad Bonni, Harvard Medical School; David Sweatt, University of Alabama at Birmingham. linkurl:Free F1000 Evaluation; linkurl:2. Mechanotransduction proteins found; family of proteins, called Piezos, has been identified as important players in mechanically activated ion channels, which make possible several senses, such hearing, touch and pain sensation.B. Coste, et al., Science, 330:55-60, 2010. Evaluations by Felix Viana, UMH Instituto de...
J. Tcherkezian, et al., Cell, 141:632-44, 2010. Evaluations by Kristen Kwan and Chi-Bin Chien, Univ Utah; Jacki Heraud and Michael Kiebler, Ctr for Brain Res, Med Univ Vienna, Austria; Wes Kroeze and Bryan Roth, Univ North Carolina; Luc Desgroseillers, Univ Montreal, Canada; Linda Columbus, Univ Virginia. linkurl:Free F1000 Evaluation; T. Shimamura, et al., Science, 328:470-3, 2010. Evaluations by Louis De Felice, Virginia Commonwealth Univ; Baruch Kanner, Hebrew Univ Hadassah Medical School, Israel; Robert Vandenberg, Univ of Sydney, Australia; Gary Rudnick, Yale Univ School of Medicine. linkurl:Free F1000 Evaluation; L. Kang, et al., Neuron, 67:381-91, 2010. Evaluations by Rachel Wilson, Harvard Medical School; Andy Groves, Baylor College of Medicine; Paul Garrity, Brandeis Univ; Roger Hardie, Univ of Cambridge. linkurl:Free F1000 Evaluation; Q. Ji, et al., Nat Immunol, 11:628-34, 2010. Evaluations by E. Charles Snow, Univ. of Kentucky Medical Center; Nick Gascoigne, The Scripps Research Institute; Barry Rouse, Univ of Tennessee; Ken Coppieters and Matthias von Herrath, La Jolla Institute for Allergy and Immunology. linkurl:Free F1000 Evaluation;
Colored scanning electron micrograph
of a section through the human inner ear.

G. Brederg/Photo Researchers, Inc.
K. Oshima, et al., Cell, 141:704-16, 2010. Evaluations by Nicolas Daudet and Azel Zine, INSERM U583; Ajay Chitnis, NICHD/NIH; Andy Groves, Baylor Coll of Med. linkurl:Free F1000 Evaluation;

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