#1 Neurons complete hippocampus loop There's a new, important function for a once-obscure cell population in the brain: CA2 pyramidal neurons, a subset of cells in the hippocampus, form a link between electrical inputs and outputs in the hippocampus. V. Chevaleye et al., "Strong CA2 pyramidal neuron synapses define a powerful disynaptic cortico-hippocampal loop," linkurl:Neuron,;http://www.ncbi.nlm.nih.gov/sites/entrez/20510860?dopt=Abstract&holding=f1000,f1000m,isrctn 66:560-72, 2010. linkurl:Eval by;http://f1000biology.com/article/z0w6412lm929myg/id/3514956/evaluation/sections Stephen Fitzjohn and Graham Collingridge, MRC Centre for Synaptic Plasticity, UK; Johannes Hell, University of California, Davis.
#2 Non-overlapping neurons The medial entorhinal cortex, a hub for memory and navigation in the brain, consists of two tangled but functionally separate networks that have different long-range axonal targets, and thus may be involved in different functions in the brain. The finding offers insights to how neural networks function, and -- in conditions like epilepsy -- dysfunction. C. Varga et al., "Target-selective...
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Image: linkurl:Wikimedia Commons, Neurollero;http://www.flickr.com/photos/neurollero/17873944/in/set-366106/ |
#3 "We're going to need a bigger model"M.W. Remme et al., "Democracy-independence trade-off in oscillating dendrites and its implications for grid cells," linkurl:Neuron,;http://www.ncbi.nlm.nih.gov/sites/entrez/20471355?dopt=Abstract&holding=f1000,f1000m,isrctn 66:560-72, 2010. linkurl:Eval by;http://f1000biology.com/article/pywfn2bz9pshgy8/id/3548974/evaluation/sections Lisa Giocomo and Edvard Moser, Norwegian University of Science and Technology, Norway; Neil Burgess, University College London.#4 Key step to making dendritesC. elegans.M. Oren-Suissa et al., "The fusogen EFF-1 controls sculpting of mechanosensory dendrites," linkurl:Science,;http://www.ncbi.nlm.nih.gov/sites/entrez/20448153?dopt=Abstract&holding=f1000,f1000m,isrctn 328:1285-8, 2010. linkurl:Eval by;http://f1000biology.com/article/5zcyjj2v5q1y4gd/id/3929957/evaluation/sections Tina Schwabe and Thomas Clandinin, Stanford University, California; Andrew Chisholm, University of California, San Diego.#5 How amyloid kills synapsesM. Renner et al., "Deleterious effects of amyloid beta oligomers acting as an extracellular scaffold for mGluR5," linkurl:Neuron,;http://www.ncbi.nlm.nih.gov/sites/entrez/20547131?dopt=Abstract&holding=f1000,f1000m,isrctn 66:739-54, 2010. linkurl:Eval by;http://f1000biology.com/article/dtzwfjsgrfrv59p/id/3743957/evaluation/sections Joel Bockaert, Institute of Functional Genomics, France; Hui-Chen Lu and Kenneth Mackie, Indiana University. #6 New mechanism for synaptic plasticityR. Scholz et al., "AMPA receptor signaling through BRAG2 and Arf6 critical for long-term synaptic depression," linkurl:Neuron,;http://www.ncbi.nlm.nih.gov/sites/entrez/20547133?dopt=Abstract&holding=f1000,f1000m,isrctn 66:768-80, 2010. linkurl:Eval by;http://f1000biology.com/article/fqxs35cc3srtcmh/id/3606964/evaluation/sections Stephen Fitzjohn and Graham Collingridge, MRC Centre for Synaptic Plasticity, UK; Johannes Hell, University of California, Davis. #7 Cell division affects cell fateP. Alexandre et al., "Neurons derive from the more apical daughter in asymmetric divisions in the zebrafish neural tube," linkurl:Nat Neurosci,;http://www.ncbi.nlm.nih.gov/sites/entrez/20453852?dopt=Abstract&holding=f1000,f1000m,isrctn 13:673-9, 2010. linkurl:Eval by;http://f1000biology.com/article/zpy3twwp0r1hh2k/id/3565956/evaluation/sections Judith Eisen, University of Oregon; Caren Norden and William Harris, University of Cambridge, UK.
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