ANDREW MEEHAN and RICK CONTRERAS
While a complete picture of the relationship between food, genes
13% Relative increase in high density lipoprotein (HDL) levels among women who ate high amounts of polyunsaturated fats and had the A allele in the promoter region of APOA1, compared with those with the more common G allele who ate similar amounts of unsaturated fat.1
0.44% Percentage of Caucasians found homozygous for the 282C/Y mutation on the HFE gene, placing them at high risk of hemochromatosis or iron overload.3
2 Number of alleles on the lactase gene associated with lactase persistence in 77% of European Americans.5
68% Decrease in colorectal cancer risk among men who consumed adequate folate and were homozygous for the 677C/T mutation in 5,10-methylenetetrahydrofolate reductase (MTHFR) compared with men heterozygous or homozygous normal at that allele. The protective effect disappeared in men who were folate deficient.6
58 million are salt-sensitive--their mean arterial blood pressure increases at least 10% with a high-salt diet-and therefore at greater risk of hypertension.
The gene responsible is unknown.7
76 Number of days it took for rats fed resveratrol, a polyphenol in grape skins, to develop tumors after breast cancer was induced, compared with 57 days in control rats and 51 days in rats fed EGCG, a polyphenol in green tea.3
2. D.C. Dolinoy et al., "Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome," Environ Health Perspect, 114:567-72, 2006.
3. T.G. Whitsett et al., "Resveratrol, but not EGCG, in the diet suppresses DMBA-induced mammary cancer in rats," J Carcinogen, 5:15, 2006.
4. P.C. Adams et al., "Hemochromatosis and iron-overload screening in a racially diverse population," N Engl J Med, 352:1769-78, 2005.
5. T. Bersaglieri et al., "Genetic signatures of strong recent positive selection at the lactase gene," Am J Hum Genet,74:1111-20, 2004.
6. J. Ma et al., "Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer," Cancer Res, 57:1098-102, 1997.
7. H. Sanada et al., "Single-nucleotide polymorphisms for diagnosis of salt-sensitive hypertension," Clin Chem, 52:352-60, 2006