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Growing a New Antidepressant

Growing a New Antidepressant Nine years ago, Rusty Gage shattered a neuroscience dogma when he showed human brains give birth to new neurons. Today, a company is eager to take those findings to the clinic.By Kerry Grens ARTICLE EXTRAS 1 and Liz Gould and Bruce McEwen at Rockefeller had published a suite of studies on the effects of stress on neurogenesis in rodents.2 But the field was sparkling wi

Kerry Grens
Kerry Grens
Mar 31, 2007
Growing a New Antidepressant

Nine years ago, Rusty Gage shattered a neuroscience dogma when he showed human brains give birth to new neurons. Today, a company is eager to take those findings to the clinic.
By Kerry Grens

ARTICLE EXTRAS

1 and Liz Gould and Bruce McEwen at Rockefeller had published a suite of studies on the effects of stress on neurogenesis in rodents.2 But the field was sparkling with newness, and huge questions remained. "At the time there was speculation about the modulatory factors of neurogenesis. Kempermann already showed exercise and an enriched environment increased it. But what are the molecular components?"

"The failures in central nervous system drugs have tended to be late and for failure of efficacy, in part because there hasn't been a good biological basis for [the action of drugs on] many of these diseases, particularly in psychiatry." --Jim Schoeneck

There were hints that...