Interactome Yields Data, But Is It Significant?

FEATUREHuman Interactome Project Interactome Yields Data, But Is It Significant? An investment of $100 million should be enough to correlate the genome with function, and identify new basic research and drug targets BY JEFFREY M. PERKELARTICLE EXTRASRelated Articles: Time for a Human Interactome Project?An investment of $100 million should be enough to correlate the genome with function, and identify new

Jeffrey M. Perkel
Feb 28, 2006
FEATURE
Human Interactome Project

Interactome Yields Data, But Is It Significant?

An investment of $100 million should be enough to correlate the genome with function, and identify new basic research and drug targets

The first human interactome maps, published just last year, offer literally thousands of starting points for further research.1,2 Yet subsequent analyses also demonstrate just how difficult it can be to convert interaction data into reliable hypotheses.

Both Marc Vidal and Erich Wanker, who published his map first, used their data to identify novel interactions. For example, Wanker identified new partners for the protein emerin, a mutation that leads to Emery-Dreifuss muscular dystrophy, as well as novel modulators of the...