Model of insulin's influence on amyloid β

By Kerry Grens LITERATUREARTICLE EXTRASRelated ArticleAlzheimer's: Type 3 Diabetes?Channel CandidatesA Channel at LargeThe Inner Workings of Hearing MachineryCracking Open a New Channel FamilyFacelessness, facedThe singing earBaby brain bankOpening Potassium Channels to ScrutinyDownstream of insulin signaling are links to amyloid β (Aβ), the principle peptide that forms the plaqu

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Kerry Grens

Kerry served as The Scientist’s news director until 2021. Before joining The Scientist in 2013, she was a stringer for Reuters Health, the senior health and science reporter at...

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Downstream of insulin signaling are links to amyloid β (Aβ), the principle peptide that forms the plaques in brains of patients with Alzheimer's disease. It begins with insulin receptor activation turning on the phosphoinositide kinase, PI3K, which generates the lipid messenger, PIP3. PIP3 activates the signaling protein AKT (serine/threonine kinase).

AKT can affect Aβ in two ways. One is that AKT mediates the upregulation of insulin degrading enzyme, IDE, which not only breaks down insulin, but is also thought to degrade Aβ. Conversely, AKT restricts GSK3β, a kinase thought to be involved in stimulating Aβ production. The activation of either pathway can therefore reduce Aβ levels, either by degrading the...

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