First-Generation Antipsychotic Drugs
|Prochlorperazine||October 1956||Severe nausea and vomiting; schizophrenia; non-psychotic anxiety||D2 receptor blockade||N/A||Contraindicated for comatose states or in the presence of large doses of CNS depressants, pediatric surgery and children under two years old or under 20 pounds; extrapyramidal symptoms, TD, NMS, cholestatic jaundice, leukopenia, agranulocytosis||IM, IV|
|Perphenazine||February 1957||Schizophrenia; severe nausea and vomiting in adults||D2 receptor blockade||$17.30, (8 mg/day)||Contraindicated in the presence of existing blood dyscrasias, bone marrow depression, or liver damage, and for patients who are comatose, greatly obtunded, on large doses of CNS depressants, or with subcortical brain damage;...|
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