Second-Generation Antipsychotic Drugs
This table lists the atypical antipsychotics. For a story on the lessons of the CATIE trial, click here. For a table of first-generation drugs, click here. For a table of drugs in the pipeline, click here.
|Clozapine||Clozaril (Novartis) FazaClo (now available as a generic) (Azur Pharma)||September 1989 (Clozaril); February 2004 (FazaClo)||Treatment-resistant schizophrenia||Interferes with binding of dopamine D1, D2, D3 and D5 receptors; affinity for D4, also has affinity for serotonergic receptors||$313.85, (600 mg/day)||Agranulocytosis, eosinophilia, seizure, myocarditis, weight gain, diabetes mellitus, NMS, TD, IMDRP||"Clozapine is different from every other drug out there," says Joseph Coyle of Harvard Medical School. For example, 90% of schizophrenia patients smoke, says Coyle. On Clozapine, 50% of them stop smoking. Clozapine also has the highest frequency...|