Supplement: The next generation?

The next generation? ARTICLE EXTRAS The Treatments A Troubled History First-Generation Antipsychotic Drugs The Atypical Atypical? The Lessons of CATIE Second-Generation Antipsychotic Drugs Beyond Drugs Nonmedication Therapies This table lists a selection of antipsychotics in the pipeline. For a story on a new class of drugs some are referring to as the "atypical atypicals," click here. For a table of first-generation drugs, click here. For a table of a

The Scientist Staff
Dec 1, 2007
The next generation?

This table lists a selection of antipsychotics in the pipeline. For a story on a new class of drugs some are referring to as the "atypical atypicals," click here. For a table of first-generation drugs, click here. For a table of atypicals, click here.

Name Primary target Phase Manufacturer
Bifeprunox D2 partial, 5-HT1A agonist III Solvay D1, D2, D3, D4 and D5 are the five receptor types for the hormone and neurotransmitter dopamine.

5-HT (5-hydroxytryptamine) refers to the group of receptors for the neurotransmitter serotonin. Each receptor is labeled 1A, 1B, 1D, etc..

Metabotropic glutamate receptors (mGluRs) bind to glutamate, an amino acid and neurotransmitter.

The adenosine receptors, for the nucleoside and neurotransmitter adenosine, are labeled with A followed by...