Supplement: Ultraviolet Light and Dermatomyositis

Ultraviolet Light and Dermatomyositis ARTICLE EXTRAS Too Much to Untangle Ultraviolet Light and Lupus Drugs, Diet, and Lupus Smoking and Rheumatoid Arthritis Iodine and Autoimmune Thyroid Disease Dermatomyositis is a connective-tissue disease that is characterized by inflammation of the skin and the muscles. Exposure to sunlight, either occupationally or recreationally, is anecdotally associa

Michael Szpir
May 1, 2007

Dermatomyositis is a connective-tissue disease that is characterized by inflammation of the skin and the muscles. Exposure to sunlight, either occupationally or recreationally, is anecdotally associated with flare-ups and even with onset of the condition in some cases. Inspired by those stories, Frederick Miller, chief of the environmental autoimmunity group at the National Institutes of Health, and his colleagues performed the first worldwide evaluation of dermatomyositis to determine whether ultraviolet radiation could explain variations in the frequency of disease.

"We did an evaluation of many centers around the world and found that the proportion of patients who have dermatomyositis or the anti-Mi-2 autoantibody strongly correlated with the amount of UV light measured at that location," says Miller. In contrast, the frequency of a...

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