Systems biology at biotechnology and pharmaceutical companies
In an effort to restock the dwindling pipeline of new treatments, systems biology is increasingly becoming a part of drug discovery efforts.
Company | Approach | Location |
Screen novel compounds with combinations of human primary cells to measure activity and understand their mechanism of action | | |
Use models to improve quality of pre-clinical compounds and guide the design of clinical trials.? Evaluate cardiovascular safety with Visual Heart.? | | |
Apply causal-inference models to identify biomarkers for drug toxicity, drug resistance, and cardiovascular drug mechanisms. | | |
Rosetta Inpharmatics | Identify targets in gene networks regulating obesity, diabetes, and other phenotypic traits, using microarray techniques. | |
Use a human physiological model designed for understanding disease dynamics and optimizing drug and treatment schedules | | |
Use virtual patients, recently modeling skin sensitivity for the... |
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