Table: Selected TLR Ligands in Clinical Trials

Table: Selected TLR Ligands in Clinical Trials Product Target Manufacturer Condition Phase Intervention Status CPG7909 TLR9 Coley Pharmaceutical Group Lymphoma I/II CpG injections and radiotherapy http://www.clinicaltrials.gov/ct/show/NCT00185965 Ongoing Coley/Pfizer Metastatic breast cancer, renal cell cancer, T-cell lymphoma, non-small cell lung cancer, melanoma I or II CpG injection with or without chemotherapy http://www.cli

Kate Travis
Jan 1, 2007

Table: Selected TLR Ligands in Clinical Trials

Product
Target
Manufacturer
Condition
Phase
Intervention
Status
CPG7909 TLR9 Coley Pharmaceutical Group Lymphoma I/II CpG injections and radiotherapy
http://www.clinicaltrials.gov/ct/show/NCT00185965
Ongoing
Coley/Pfizer Metastatic breast cancer, renal cell cancer, T-cell lymphoma, non-small cell lung cancer, melanoma I or II CpG injection with or without chemotherapy
http://www.clinicaltrials.gov/ct/show/NCT00043407
http://www.clinicaltrials.gov/ct/show/NCT00043420
http://www.clinicaltrials.gov/ct/show/NCT00070629
http://www.clinicaltrials.gov/ct/show/NCT00070642
Ongoing and completed
Malaria I Malaria vaccine with and without CpG 7909
http://www.clinicaltrials.gov/ct/show/NCT00320658
Recruiting
CPG10101 TLR9 Coley Pharmaceutical Group Hepatitis C II Pegylated interferon plus ribavirin with or without CPG 10101 in hepatitis C patients
http://www.clinicaltrials.gov/ct/show/NCT00277238
Recruiting
1018 ISS TLR9 Dynavax Allergy II ISS conjugated to ragweed allergen given to patients with allergic rhinitis
http://www.clinicaltrials.gov/ct/show/NCT00346086
Completed
B-cell follicular lymphoma II ISS given in conjunction with Rituxan
http://www.clinicaltrials.gov/ct/show/NCT00251394
Recruiting
Metastatic colorectal cancer I ISS in combination with irinotecan and cetuximab
http://www.clinicaltrials.gov/ct/show/NCT00403052
Recruiting
Hepatitis B II ISS with hepatitis B surface antigen compared with commercial hepatitis vaccine
(completed...

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