The brain on drugs
The brain on drugs Drugs elevate CREB activity in the nucleus accumbens by activating cyclic AMP pathway, causing protein kinase A to translocate to the nucleus and phosphorylate CREB. Target genes involved in addiction include dynorphin, corticotropin releasing hormone (CRH or CRF ), brain-derived neurotrophic factor (BDNF), tyrosine hydroxylase (TH), glutamate receptor subunit GluR1.By Kerry Grens ARTICLE EXTRAS Addictive Research Ho
Kerry served as The Scientist’s news director until 2021. Before joining The Scientist in 2013, she was a stringer for Reuters Health, the senior health and science reporter at...
View full profile.
Learn about our editorial policies.
The brain on drugs
Drugs elevate CREB activity in the nucleus accumbens by activating cyclic AMP pathway, causing protein kinase A to translocate to the nucleus and phosphorylate CREB. Target genes involved in addiction include dynorphin, corticotropin releasing hormone (CRH or CRF ), brain-derived neurotrophic factor (BDNF), tyrosine hydroxylase (TH), glutamate receptor subunit GluR1.
By Kerry Grens
Interested in reading more?
Become a Member of
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member?
