The RNA Conductome

The RNA Conductome What can we learn from the in-process encyclopedia of how non-protein-coding sequences exert genetic control? The Scientist Staff Over the years, scientists and drug companies seeking genetic control over biological systems have focused their attention on proteins. But that's only one part of the picture: Recently, scientists have been accumulating evidence that non-protein-coding sequences often play the role of conductor in the body's response: it'

The Scientist Staff
Oct 1, 2007

The RNA Conductome

What can we learn from the in-process encyclopedia of how non-protein-coding sequences exert genetic control?

The Scientist Staff

Over the years, scientists and drug companies seeking genetic control over biological systems have focused their attention on proteins. But that's only one part of the picture: Recently, scientists have been accumulating evidence that non-protein-coding sequences often play the role of conductor in the body's response: it's a kind of "conductome". Now this information is becoming encyclopedic, and it is calling into question everything we thought we knew about the so-called functional genome.

In the following pages, we illustrate the roles of microRNAs - the small non-coding RNAs that regulate gene expression by interfering with messenger RNA function - in biological systems. We also present a controversial new definition of the functional genome from John Mattick, based at the University of Queensland, who argues that so-called junk DNA provides...