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Top 7 From F1000

Top 7 From F1000 1. How fat causes diabetes» There are new molecular links between obesity and diabetes—a high-fat diet in mice activates proteins associated with obesity, but these changes can be reversed by a well-known diabetes drug, suggesting the same pathway may also cause insulin-resistance. J.H. Choi et al., Nature, 466:451-56, 2010. Evaluated by L. Hamann, Novartis; M. Andresen, OHSU; P. Webb, TMHRI. Free F1000 EvaluationRelated Articles

The Scientist Staff

Top 7 From F1000

1. How fat causes diabetes» There are new molecular links between obesity and diabetes—a high-fat diet in mice activates proteins associated with obesity, but these changes can be reversed by a well-known diabetes drug, suggesting the same pathway may also cause insulin-resistance.

J.H. Choi et al., Nature, 466:451-56, 2010. Evaluated by L. Hamann, Novartis; M. Andresen, OHSU; P. Webb, TMHRI. Free F1000 Evaluation

2. A new metabolism » A novel metabolic pathway in the malaria parasite differs significantly from the classic Krebs cycle taught in textbooks, providing evidence that carbon metabolism can evolve.

K.L. Olszewski et al., Nature, 466:774-78, 2010. Evaluated by P. Roepe, Georgetown; R. Abraham, Pfizer. Free F1000 Evaluation

3. Double-edged gene » Two gene variants found commonly in African genomes, which appear to explain why...

G. Genovese et al., Science, 329:841-45, 2010. Evaluated by W. Gibson, Univ Bristol; M. Breyer, Lilly Res Lab; C. Clayton, Univ Heidelberg; M. Parsons, Seattle Biomed. Free F1000 Evaluation

4. Focal structure » For the first time, researchers have described the three-dimensional molecular structure of focal adhesions, providing insights into how they secure cells to the extracellular matrix and participate in mechanosensory events.

I. Patla et al., Nat Cell Biol, 12:909-15, 2010. Evaluated by R. Zaidel-Bar, Nat Univ Singapore; M. Himmel and S. Linder, UKE. Free F1000 Evaluation

5. How neurons grow » There’s another layer of complexity in the developing nervous system: Spontaneous neuronal activity can regulate the differentiation of neurons, affecting swimming behavior in frog larvae.

M. Demarque et al., Neuron, 67:321-34, 2010. Evaluated by K. Sillar, Univ St Andrews; J.S. Eisen, Univ Oregon; A. Marín-Burgin and A. Schinder, Leloir Inst. Free F1000 Evaluation

6. Retinal roles » Photosensitive ganglion cells, which were only discovered in the mammalian retina in the early 1990s, play a greater role in visual function than previously believed.

J.L. Ecker, Neuron, 67:49-60, 2010. Evaluated by R. Hardie, Univ Cambridge; S. Reppert, UMass Med. Free F1000 Evaluation

7. How cilia talk » Primary (nonmotile) cilia need membrane proteins to send and receive extracellular signals as part of their role as a coordinator of signaling pathways, and new findings show how cilia retain those membrane proteins—a barrier at the base of cilia made up of proteins called septins.

Q. Hu et al., Science, 329:436-39, 2010. Evaluated by Y. Barral, ETH; M. Wirschell and W. Sale, Emory; H. Folsch, Northwestern; Y. Yamashita, UMich; M. Bettencourt-Dias, IGC; S. Feng and W. Guo, UPenn; M. Labouesse, CNRS; J. Axelrod, Stanford. Free F1000 Evaluation

The F1000 Top 7 is a snapshot of the highest-ranked articles from a 30-day period on Faculty of 1000 Biology. Faculty Members evaluate and rate the most important papers in their field. To see the latest rankings, search the database, and read daily evaluations, visit http://f1000.com/.

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