You give me fever
V. Nene et al., “Genome sequence of Aedes aegypti, a major arbovirus vector,” Science, 316:1718–23, 2007. (Cited in 100 papers)
Five years after scientists sequenced the malaria vector Anopheles gambiae, researchers at the J. Craig Venter Institute and the University of Notre Dame released the genetic blueprint of a second mosquito, Aedes aegypti, the species that spreads yellow and dengue fevers. With two mosquito genomes, researchers may develop genomics-based explanations of mosquito behavior and the pathogens they transmit, says Peter Atkinson of the University of California, Riverside.
Over the 150 million years since the mosquito lineages split, the Ae. aegypti genome ballooned to five times the size of A. gambiae’s. This enlargement was driven by a surge of transposable elements, which make up around half of Ae. aegypti’s 1.4 billion...
Imperial College London’s George Christophides showed that immune signaling pathways in the two mosquito genomes are fairly similar, but highly diverged from the fruit fly’s (Science, 316:1738–43, 2007). “These immunity differences might be explained by the insects’ different diets and pathogen exposures,” Christophides says.
Researchers have recently sequenced three more human disease vectors—another mosquito, Culex quinquefasciatus; a body louse, Pediculus humanus; and a tick species, Ixodes scapularis—and created a web portal called VectorBase (www.vectorbase.org) to interrogate all five disease-carrier genomes.
|Genome size (Mb)||No. of genes||Average gene length (bp)|