genetics

Single-Cell Spatial Transcriptomics with Cleavable Fluorescent Probes 

In this webinar, Jia Guo discusses the basics of in situ hybridization and how to use novel fluorescent probes for ultra-sensitive single-cell resolution in situ genomics.

This webinar will be hosted live and available on-demand

Tuesday, November 22, 2022 
2:30 PM Eastern Time 

Scientists use in situ hybridization (ISH) to reveal the location of specific nucleic acid sequences within cells, which is a crucial step for understanding gene organization, regulation, and function. In situ hybridization can preserve spatial information, which avoids the masking of cellular heterogeneity that comes with bulk analysis. 

In this Technique Talk, Jia Guo will explore the fundamentals of ISH and the development and use of novel in situ hybridization technology to investigate complex biological systems.

Learning Objectives

  • How multiplexed fluorescent ISH works
  • Mild yet efficient methods for removing signal
  • Ways to amplify signal
  • Detecting short RNA species in formalin-fixed paraffin-embedded (FFPE) tissues


Jia Guo, PhD
Associate Professor
Biodesign Institute and School of Molecular Sciences
Arizona State University