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Novel In-vivo Imaging Solution for Neuroscientists

Prior Scientific reports that its collaboration with Neurotar (Helsinki, Finland) has produced a seamlessly integrated solution for in vivo microscopic imaging in the brain of awake and moving rodents. The solution is based upon Prior’s ultra-stable and easily adjustable Z-Deck platform.. 

The Scientist Staff

Neurotar’s Mobile HomeCage™ is an accessory device for microscopy and electrophysiology, which enables high precision tests in the brain of awake, head-fixed, but otherwise freely moving rodents. The Mobile HomeCage eliminates the need for anaesthesia and thus preserves full physiological functioning of the brain. It provides a natural, tangible environment, which alleviates the stress experienced by rodents during experiments under standard head-fixation conditions. Stress reduction helps reduce the run-up time to the start of experiments and improves their reproducibility. The Mobile HomeCage is compact – it fits into most imaging set-ups without the need for modifications. Last but not least, it allows combining state-of-the-art neurophysiological techniques (such as in vivo two-photon microscopy, optogenetics, intrinsic optical imaging and in vivo patch-clamp) with behavioral paradigms in a single experiment.

Working closely with Neurotar, Prior have developed a fixing kit allowing seamless integration of the Mobile HomeCage with the Z-Deck....

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