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Abstract 3D rendering of a heterogeneous protein mixture
Article

Verify the Oligomeric Mix in Sixty Seconds

Explore how mass photometry delivers absolute mass measurements in native buffers across three protein systems

Brought to you byRefeyn

A downstream result reflects the sample behind it. Before committing to structural analysis or functional assays, oligomeric composition is the variable that shapes the data. Yet standard methods report an averaged signal across the population, not the individual species inside it.

The MyMassMP application note demonstrates how to map the distribution of monomers, dimers, and aggregates in a single minute. The data shows how label-free mass photometry resolves constituent species that bulk methods obscure, one molecule at a time.

Download the application note to

  • See absolute mass and ratio data across three distinct protein systems, including the pH-dependent dimer-to-monomer shift in thyroglobulin
  • Learn how mass photometry resolves heterogeneity that gel- and column-based methods cannot
  • Evaluate sample compatibility with 30 µL volumes at low nanomolar concentrations, with 1–2 percent mass accuracy from 55 kDa to 3 MDa

Sponsored by

  • Refeyn

Top Image Credit:

©iStock, Pobytov

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