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Modern Prosthesis

See amputee Amanda Kitts manipulate objects using nervous impulses to control an early prototype of her advanced artificial limb.

The Scientist Staff

Sep 26, 2018

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Magenta (DNA) and green (lysosome) fluorescent markers indicate that cells eject waste products from the cell before late mitosis.

Science Snapshot: Mitotic Housekeeping

Gut Microbes Help Ground Squirrels Endure Hibernation

MUSCLE CONTROL: Researchers pinpoint how C. elegans (pictured) manages to expel food from its mouth.

The Science Behind How Roundworms Spit

Infographic showing endogenous adenosine enzymes acting on RNA (ADARs) edit genetic material in the cell by attaching to naturally occurring double-stranded RNAs, including mRNAs, and switching out A bases with I bases (left). Therapeutic RNA editing platforms based on this mechanism fall into one of two categories: either they use engineered enzymes, which generally consist of the editing part of the ADAR enzyme attached to another protein such as Cas13 that boosts specificity, alongside a guide RNA that targets the enzyme to the desired location (middle); or they consist of a guide RNA alone, which recruits an endogenous ADAR to edit the target sequence (right).

Infographic: RNA Editing Approaches

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