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A Researcher’s Best Friend

Meet Joey Ramp, a University of Illinois neuroscience student who is fighting to continue her education with her service dog by her side.

The Scientist Staff

Oct 31, 2018

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Magenta (DNA) and green (lysosome) fluorescent markers indicate that cells eject waste products from the cell before late mitosis.

Science Snapshot: Mitotic Housekeeping

Dogs of various breeds running in the field.

They’re All (Potentially) Good Dogs

Infographic showing endogenous adenosine enzymes acting on RNA (ADARs) edit genetic material in the cell by attaching to naturally occurring double-stranded RNAs, including mRNAs, and switching out A bases with I bases (left). Therapeutic RNA editing platforms based on this mechanism fall into one of two categories: either they use engineered enzymes, which generally consist of the editing part of the ADAR enzyme attached to another protein such as Cas13 that boosts specificity, alongside a guide RNA that targets the enzyme to the desired location (middle); or they consist of a guide RNA alone, which recruits an endogenous ADAR to edit the target sequence (right).

Infographic: RNA Editing Approaches

tibetan mastiff with ghostly wolves in the background

The Extinct Species Within

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