Infographic: Salmonella Shuttle Tumor Antigens to Immune Cells

Nanoparticle-coated bacteria carry cancer-derived proteins to dendritic cells, enabling the immune system to launch a response in a mouse model.

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Dan Robitzski

Dan is a Staff Writer and Editor at The Scientist. He typically works on the news desk and joined the team in 2021. He has a background in neuroscience and earned his master's in science journalism at New York University.

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May 16, 2022

Following radiation therapy, which triggers the release of cancer-specific antigens, researchers injected Salmonella typhimurium bacteria covered in positively charged nano-particles near tumors in mice. The bacteria captured the negatively charged antigens and ferried them to dendritic cells in the tumors’ periphery, where a tumor-targeting immune response was initiated, improving the animals’ odds of survival.

Illustration showing how following radiation therapy, which triggers the release of cancer-specific antigens, researchers injected Salmonella typhimurium bacteria covered in positively charged nano- particles near tumors in mice.
© Kelly Finan

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This article was featured in May 2022, Issue 2 of the digest