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Two hands holding tweezers and dissecting single points in a DNA sequence.
From CRISPR to Prime Editing: The Evolution of the Genome Editing Revolution
Even as CRISPR-based tools become a lab staple, scientists strive to tackle the associated technological challenges to improve their efficacy and safety.   
From CRISPR to Prime Editing: The Evolution of the Genome Editing Revolution
From CRISPR to Prime Editing: The Evolution of the Genome Editing Revolution

Even as CRISPR-based tools become a lab staple, scientists strive to tackle the associated technological challenges to improve their efficacy and safety.   

Even as CRISPR-based tools become a lab staple, scientists strive to tackle the associated technological challenges to improve their efficacy and safety.   

News

A dark blue T cell with light blue and yellow structures on its surface.
Epigenetic Clocks Continue to Tick Over Multiple Lifetimes
Hannah Thomasy, PhD | Sep 17, 2024 | 5 min read
Murine T cells that survived at least four host lifetimes offer insights into immunological senescence. 
Image of blue and red worms navigating across a maze from left to right. The far right depicts a finish line for the worms.
Drunk Worms Wiggle Their Way to an Ig Nobel Win
Laura Tran, PhD | Sep 12, 2024 | 4 min read
University of Amsterdam researchers claimed the 2024 Ig Nobel Prize in Chemistry for studying polymers by racing inebriated and sober worms through a chromatography maze.
Abstract, colorful illustration of the human brain
A Gene Therapy to Treat the FOXG1 Brain Disorder 
Niki Spahich, PhD | Sep 12, 2024 | 4 min read
By postnatally providing a transcription factor important for brain development, researchers fixed abnormalities generated in utero in mice.
A steam train going over a viaduct.
Cellular Trains Make a Quick Getaway
Kamal Nahas, PhD | Sep 11, 2024 | 4 min read
Clusters of epithelial cells migrate at different speeds depending on their layout, with single-file assemblies making the fastest journeys.
Illustration of blue and purple mitochondria.
Multifaceted Mitochondria Maintain Mystique
Shelby Bradford, PhD | Sep 11, 2024 | 3 min read
Tiny but mighty, the mitochondria continue to surprise scientists with new insights into their diverse roles within cells.
A close-up picture of a fruit fly.
A Neural Circuit That Helps Flies Stay on Course
Mariella Bodemeier Loayza Careaga, PhD | Sep 10, 2024 | 5 min read
Two studies tapped into the brain circuitry that allows fruit flies to navigate, offering clues to key principles that may govern navigation in more complex brains.
Illustration of chains of amino acids forming proteins show in light blue against a dark blue background.
Protein Changes in the Brain Could Explain How Neurodevelopment Goes Awry
Claudia Lopez-Lloreda, PhD | Sep 10, 2024 | 4 min read
Long-read sequencing uncovered hundreds of thousands of new isoforms not previously identified during development.
Illustration of a scientist at a high-containment laboratory. He is dressed in a Tyvek suit with a helmet respirator for being in the BSL-3 and is unpacking a box of lab supplies.
Career Chat: Directing a New Science Path
Shelby Bradford, PhD | Sep 9, 2024 | 3 min read
A professional detour veered Ludovic Desvignes into a high-maintenance career—director of a high-containment facility.
Image of a cancer cell skipping across the water. 
Skipping Toward Resistance: The Gradual Adaptation of Cancer Cells 
Laura Tran, PhD | Sep 6, 2024 | 4 min read
Instead of an on-off toggle switch, cancer cells adapt through a series of distinct states of increasing drug resistance.
This image shows hexagon shaped cells (mouse airway stem cells) that are outlined in magenta. Within each cell there are tiny dots that represent centrioles, which are colored cyan. 
Introducing a New Version of the Cell Cycle
Maggie Chen | Sep 6, 2024 | 4 min read
Scientists have identified a new variant of the cell cycle that could provide insight into how diseases like cancer occur. 
A wound that is covered with a band-aid.
Why Pain During Wound Healing May be a Good Sign
Sneha Khedkar | Sep 5, 2024 | 4 min read
Sensory neurons grow into injured tissues and modulate the immune system to promote healing.
An artist’s representation of the human respiratory system with pink airways on a blue and black background.
A Gene Editing System Corrects Cystic Fibrosis Mutation
RJ Mackenzie | Sep 4, 2024 | 4 min read
An optimized version of prime editing technology raises the possibility of a one-time treatment for cystic fibrosis.
A syringe inserted into a vial of vaccine.
Engineered Yeast Brew a Vaccine Adjuvant 
Sahana Sitaraman, PhD | Sep 3, 2024 | 3 min read
Ever since its discovery in the 1900s, the production of a potent vaccine adjuvant relied on the Chilean soapbark tree. Now, yeast can make the molecule.
Cartoon of a young girl sitting at a table looking at a collection of cartoon viruses.
Crafting Science Stories for Young Audiences
Danielle Gerhard, PhD | Sep 2, 2024 | 7 min read
Finding a narrative that resonates with the audience and serving it in their preferred format helps make science engaging, relatable, and fun.
3D illustration of a DNA molecule with sparkling effects symbolizing.
A Prime-Editing Based Approach Records Cellular Genetic History
Maggie Chen | Aug 30, 2024 | 3 min read
Researchers developed a technique, ENGRAM, to keep a running log of the elements that control gene expression in cells. 
A micrograph shows grey sickle-shaped nanovials containing single, fluorescent green mesenchymal stem cells. Some of the cells have secreted high levels of magenta-colored extracellular vesicles.
Tiny Test Tubes Sort Stem Cells for Improved Therapy
Rebecca Roberts, PhD | Aug 29, 2024 | 4 min read
Mesenchymal stem cells with high levels of extracellular vesicle secretion promote vascular regeneration and improve heart function in mice.
On the left is a brain in blue connect by blue electricity-like lines to a heart in red on the right side of the image.
Can the Brain Help Heal a Broken Heart?
Hannah Thomasy, PhD | Aug 28, 2024 | 6 min read
Stimulation of neural reward pathways may help mice recover from heart attacks.
A small blue cell undergoing cell death next to a larger amber cell with extensive projections.
Older Oligodendrocytes Live Longer Despite Damage
Nicholas Miliaras, PhD | Aug 28, 2024 | 3 min read
Tracking oligodendrocytes across their lifespans could help scientists better understand neuronal aging and degenerative diseases. 
Photograph of the end of a tattoo gun and pots of different colored ink on a napkin.
FDA Found Anaerobic Bacteria in Sealed Tattoo Inks
Shelby Bradford, PhD | Aug 27, 2024 | 3 min read
The presence of microbes in tattoo inks raises concerns regarding the products’ safety.  
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