Infographic: Simultaneously Studying Neuron Structure and Function
A new methodology combines existing techniques to reveal the specific function and location of multiple types of neurons at once.

Apr 18, 2022
First, calcium imaging provides precise neural microscopy data on the arrangement and activity of individual cells within the brain of a live mouse. Then, hybridization chain reaction–fluorescence in situ hybridization (HCR-FISH) on tissue samples yields information on the expression of specific genes of interest. Combining these imaging methodologies into a technique called comprehensive readout of activity and cell type markers (CRACK), allows researchers to elucidate a cell’s type, connections within neural circuitry, and function.

© IKUMI KAYAMA, STUDIO KAYAMA
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This article was featured in April 2022, Issue 2 of the digest