Methods

The ability to rapidly count and measure features of cells opened the research flood gates.

Vaccination has beaten back infections for more than a century. Now, it may be the next big step in battling cancer.

Recombinase polymerase amplification lets researchers rapidly replicate DNA in the clinic, in the field, or even in the International Space Station.

A combinatorial approach enabled high-throughput screening of protein libraries for desired target binding.

First developed in 2013, a fluorescent indicator has evolved to enable precise glutamate tracking.

Since the technique was first published in 2019, prime editing has grown with lightning speed, alongside hopes for what it can achieve.

A series of technological advancements for automation and parallel imaging made volume electron microscopy more user friendly while increasing throughput.

Clinicians and researchers teamed up to investigate how inappropriate proinflammatory mechanisms contribute to the pathogenesis of drug-refractory epilepsy.

An implantable device stimulates muscle contraction and prevents muscular atrophy in mice.

A new microrobot uses algae to transport antibiotics into the lungs of mice with pneumonia.

A new technique, called Unclearing Microscopy, physically inflates and then stains cells to circumvent the need for expensive microscopes.

Scientists use locust brains as living biosensors to perform cancer cell breath tests.

A wireless brain implant inhibits tumor growth in rats, overcoming many design flaws of current devices used to treat glioblastoma.

Analyzing organoids has proven slow and cumbersome for scientists. But a new technique may speed things up, producing 3D images of hundreds of organoids per hour.

A new tool called PRISM draws on virus-host interactions and a DNA repair pathway to help researchers visualize how cellular stress may contribute to neurodegenerative disease.

The approach, called GRAND, uses a second guide RNA to write complementary strands of DNA in targeted genomic locations, resulting in efficient insertions that can be hundreds of base pairs long.

A new technique reveals cells’ precise locations and functions in the brain. Its developers have already used it to identify a previously unknown neuron type.

Researchers link a stretch of DNA to a peptide of interest and measure current changes as the molecule is pulled by a helicase through a nanopore.

A technique that reversibly bundles tagged cargo into artificial membraneless compartments gives scientists the ability to switch cell processes on and off.