An abstract illustration of a tooth on a bluish background, signifying teeth that are a source of multipotent dental stem cells that can have therapeutic applications in dental diseases and beyond.

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Stem cells in the teeth and gums are multipotent and easily accessible. Scientists are researching ways to harness their power for therapies beyond dentistry.

Dental Stem Cells Regenerate More Than Just Smiles

The liquid world of fetal development provides a rich source of nutrition and protection tailored to meet the needs of the growing fetus. 

Illustration of a developing fetus surrounded by a clear fluid with a subtle yellow tinge, representing amniotic fluid.

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What Is the Amniotic Fluid Composed of? 

TS Digest

Big Roles for the "Little Brain"

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old film photograph of skeletons found in Pompeii building

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Caught on Camera

Science Snapshot

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To flag neurons that have experienced genotoxic stress, researchers developed an in vivo sensor using an adeno-associated viral vector, called PRISM. Because a cell&rsquo;s DNA damage response (DDR)&mdash;which activates in response to stressors such as environmental toxins or the buildup of misfolded proteins&mdash;also responds to invading pathogens, PRISM has an easier time transfecting cells whose damage response mechanisms are preoccupied with existing DNA damage. Once inside, the virus hijacks the neuron&rsquo;s DNA replication machinery, which reverts an engineered frameshift mutation in the virus and thereby prompts the production of a fluorescent protein that can be observed via microscopy.

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DNA Damage Viewed with Unprecedented Clarity

Methods

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Illustration of the brain&#39;s cerebellum

A cross section illustration of a cerebellum

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The Cerebellum&rsquo;s Functions in Cognition, Emotion, and More

Feature

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Humsa Venkatesh Probes Cancer&rsquo;s Grip on the Brain

Profile

Cartoon illustration of two scientists playing with miniature dinosaurs and meteors.

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Micrograph of a fragment of leaf cuticle showing epidermal cells (clustered) and a fern spore (bottom right) from a K-Pg site in southern Colorado

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Cartoon illustration of scientists playing with miniature dinosaurs and meteors.

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Ellen Currano and Alex Baer inspect plants in a greenhouse at the University of California, Santa Cruz.

Ferns bounced back much faster than other plants after the meteor impact that wiped out the dinosaurs.

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Why Did Ferns Persist When All Other Plants Perished?

Oysters’ shells were made into concrete and other materials used in construction during the Industrial Revolution.

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Oyster reefs form as the mollusks grow on a rocky underwater surface, each generation settling on the shells of the previous one.

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Divers assist on a project designed to draw oysters back to reefs in Australia.

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Oysters&rsquo; shells were made into concrete and other materials used in construction during the Industrial Revolution.

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Scientists Use Sound to Attract Baby Oysters Back to the Reef

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Cover of When Animals Dream: A colourful illustration of an octopus.<br><br>

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Cover of <em>When Animals Dream</em>: A colourful illustration of an octopus.

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Opinion: Animal Dreaming Should Give Us Ethical Pause

Article

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To flag neurons that have experienced genotoxic stress, researchers developed an in vivo sensor using an adeno-associated viral vector, called PRISM. Because a cell’s DNA damage response (DDR)—which activates in response to stressors such as environmental toxins or the buildup of misfolded proteins—also responds to invading pathogens, PRISM has an easier time transfecting cells whose damage response mechanisms are preoccupied with existing DNA damage. Once inside, the virus hijacks the neuron’s DNA replication machinery, which reverts an engineered frameshift mutation in the virus and thereby prompts the production of a fluorescent protein that can be observed via microscopy.

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Infographic: DNA Damage Viewed with Unprecedented Clarity

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Illustration showing how a cerebellum can be divided into specific regions

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Infographic: The Cerebellum&rsquo;s Many Roles Beyond Motor Control 

The cerebellum is now appreciated for its functions in cognition, emotion, and other higher-order processes