Myc, Nicked

By Richard P. Grant Myc, Nicked Wikipedia (Crystal structure of Myc and Max in complex with DNA.) The paper M. Conacci-Sorrell et al., “Myc-nick: a cytoplasmic cleavage product of Myc that promotes α-tubulin acetylation and cell differentiation,” Cell, 142:480-93, 2010. Free F1000 Evaluation The finding When Maralice Conacci-Sorrell joined Bob Eisenman’s lab at the Fred Hutchinson Cancer Research Center in Seattle, Washington, she

| 1 min read

Register for free to listen to this article
Listen with Speechify
0:00
1:00
Share

The paper

M. Conacci-Sorrell et al., “Myc-nick: a cytoplasmic cleavage product of Myc that promotes α-tubulin acetylation and cell differentiation,” Cell, 142:480-93, 2010. Free F1000 Evaluation

The finding

When Maralice Conacci-Sorrell joined Bob Eisenman’s lab at the Fred Hutchinson Cancer Research Center in Seattle, Washington, she started studying the transcription factor and major oncogene protein, Myc, and its role in cancer. But following up on an experimental anomaly, she discovered a new role for Myc in differentiation and cytoskeletal organization.

The antibody

Conacci-Sorrell was surprised to find a smaller version of the Myc protein on her Western blots. She noticed this protein present in the cell cytoplasm—which is strange because Myc should be confined to the nucleus. Despite doubts that her results were caused by a contamination, she continued to work on the protein as a side project and was able to demonstrate that the small Myc was a cleavage ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member? Login Here

Meet the Author

  • Richard P. Grant

    This person does not yet have a bio.

Published In

Share
May digest 2025 cover
May 2025, Issue 1

Study Confirms Safety of Genetically Modified T Cells

A long-term study of nearly 800 patients demonstrated a strong safety profile for T cells engineered with viral vectors.

View this Issue
Detecting Residual Cell Line-Derived DNA with Droplet Digital PCR

Detecting Residual Cell Line-Derived DNA with Droplet Digital PCR

Bio-Rad
How technology makes PCR instruments easier to use.

Making Real-Time PCR More Straightforward

Thermo Fisher Logo
Characterizing Immune Memory to COVID-19 Vaccination

Characterizing Immune Memory to COVID-19 Vaccination

10X Genomics
Optimize PCR assays with true linear temperature gradients

Applied Biosystems™ VeriFlex™ System: True Temperature Control for PCR Protocols

Thermo Fisher Logo

Products

Leica Microsystems Logo

Latest AI software simplifies image analysis and speeds up insights for scientists

BioSkryb Genomics Logo

BioSkryb Genomics and Tecan introduce a single-cell multiomics workflow for sequencing-ready libraries in under ten hours

iStock

Agilent BioTek Cytation C10 Confocal Imaging Reader

agilent technologies logo
Sapio Sciences logo

Sapio Sciences Introduces Biorepository Management Solution