Scientists use liquid chromatography-mass spectrometry (LC-MS) to quantify protein biomarkers with high sensitivity and specificity in complex sample types, including serum, plasma, and tissues. As the demand to develop and deploy consistent and reproducible LC-MS assays continues to rise, researchers need better workflows for tissue dissociation and homogenization. These steps are the greatest source of variability during sample preparation for LC-MS, and traditional methods are tedious, time consuming, and labor intensive, introducing operator variability. To address these challenges, researchers can turn to automated tissue dissociation and homogenization workflows.
Download this application note from Revvity to learn about benchmarking data and the implementation strategy by Pfizer’s R&D team when automating tissue sample weighing and homogenization for downstream LC-MS analysis.
