NEW YORK, July 24 (Praxis Press) Low-grade inflammation has been implicated in the pathogenesis of coronary artery disease (CAD). Danesh and colleagues studied the association of inflammatory markers and subsequent CAD in middle-aged British men. Coronary artery disease was associated with baseline levels of plasma C reactive protein, serum amyloid A protein, and serum albumin, and baseline leukocyte counts. However, these markers were not associated with Helicobacter pylori seropositivity, Chlamydia pneumoniae titers, or plasma homocysteine levels. Inflammatory processes of unknown etiology are associated with subsequent coronary heart disease.

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