Edited by: Karen Young Kreeger
N. Funayama, F. Fagotto, P. McCrea, B.M. Gumbiner, "Embryonic axis induction by the armadillo repeat domain of b-catenin: Evidence for intracellular signaling," Journal of Cell Biology, 128:959-68, 1995. (Cited in more than 60 publications as of February 1997)

Comments by Barry Gumbiner, Memorial Sloan-Kettering Cancer Center


DOUBLE ROLE: Sloan-Kettering's Barry Gumbiner and colleagues found that beta-catenin plays a role in signal transduction, as well as cellular adhesion.
Cadherins and beta- and alpha-catenins are proteins known to be important in cellular adhesion-the physical process by which cells adhere to each other to form tissue. beta-catenin is a widespread molecule found in almost every tissue other than blood cells.

The lab of Barry Gumbiner at Memorial Sloan-Kettering Cancer Center in New York used frog embryos to look at how the process of adhesion contributes to development. To do this, they cloned beta-catenin cDNA, which...

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