Edited by: Karen Young Kreeger
N. Funayama, F. Fagotto, P. McCrea, B.M. Gumbiner, "Embryonic axis induction by the armadillo repeat domain of b-catenin: Evidence for intracellular signaling," Journal of Cell Biology, 128:959-68, 1995. (Cited in more than 60 publications as of February 1997)
Comments by Barry Gumbiner, Memorial Sloan-Kettering Cancer Center
The lab of Barry Gumbiner at Memorial Sloan-Kettering Cancer Center in New York used frog embryos to look at how the process of adhesion contributes to development. To do this, they cloned beta-catenin cDNA, which is highly homologous to the much-studied Drosophila armadillo protein. These proteins contain regions called armadillo repeats that are also present in many other proteins, including the tumor suppressor gene product APC.
"The importance of this paper is that it introduces the first evidence for a signal transduction role for beta-catenin, as well as a role in adhesion," says Gumbiner, a cell biologist in the ...
