Cancer, obesity, and even atherosclerosis share a common set of differentially expressed genes, suggesting a diverse number of human diseases share the same disrupted biological pathways, according to new research published this week in Cancer Cell. The genetic link also suggests that drugs currently used for the treatment of metabolic and cardiovascular diseases might also be used against cancer, researchers say.
DNA microarray
Image: Wikimedia commons,
Guillaume Paumier
"In any year, there are probably ten big papers in a field that help push a concept forward," said linkurl:Reuben Shaw,; an HHMI investigator at the Salk Institute in California who was not involved in the research. "I think this is one of them." linkurl:Kevin Struhl; and colleagues at Harvard Medical School compared the transcription profiles of two genetically identical human mammary epithelial cell lines from the same individual -- one normal and one cancerous, or transformed, through the addition of...
Cancer Research

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