You give me fever

By Elie Dolgin You give me fever James Gathany / CDC The paper: V. Nene et al., “Genome sequence of Aedes aegypti, a major arbovirus vector,” Science, 316:1718–23, 2007. (Cited in 100 papers) The finding: Five years after scientists sequenced the malaria vector Anopheles gambiae, researchers at the J. Craig Venter Institute and the University of Notre Dame released the genetic blueprint of

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The paper:

V. Nene et al., “Genome sequence of Aedes aegypti, a major arbovirus vector,” Science, 316:1718–23, 2007. (Cited in 100 papers)

The finding:

Five years after scientists sequenced the malaria vector Anopheles gambiae, researchers at the J. Craig Venter Institute and the University of Notre Dame released the genetic blueprint of a second mosquito, Aedes aegypti, the species that spreads yellow and dengue fevers. With two mosquito genomes, researchers may develop genomics-based explanations of mosquito behavior and the pathogens they transmit, says Peter Atkinson of the University of California, Riverside.

The expansion:

Over the 150 million years since the mosquito lineages split, the Ae. aegypti genome ballooned to five times the size of A. gambiae’s. This enlargement was driven by a surge of transposable elements, which make up around half of Ae. aegypti’s 1.4 billion base pairs. “It’s still an open question as to why Aedes has so many” ...

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