A Cutting Edge Reply

A recent article 1 emphasized the increasing obesity within the American population, and the author criticized the Food and Drug Administration for not allowing wider use of olestra to reduce fat/caloric intake. This article crystallizes what is wrong with much health-related research today. It is a classic example of looking for a 'magic bullet' approach to a serious problem rather than making the comprehensive lifestyle changes required. I have been conducting a text-mining study on the disc

| 4 min read

Register for free to listen to this article
Listen with Speechify
0:00
4:00
Share

I have been conducting a text-mining study on the discipline of caloric restriction, focusing on the eclectic laboratory and clinical nonpathological experiences with controlled caloric restriction for health improvement, applied to all living species. Excluded are starvation, disease-caused caloric restriction, surgically-driven caloric restriction, and psychologically-driven caloric restriction (bulimia, anorexia). Preliminary results offer the following conclusions:

Thus, the hard laboratory and clinical evidence shows that caloric restriction can provide longevity and good health for small species, may provide such benefits to nonhuman primates, and may offer the potential to provide such benefits to humans. As far as I have been able to determine, controlled caloric restriction is the only regimen that has been demonstrated in the laboratory to increase life span, and therefore may be the foundational requirement for proper diet. In particular for humans, how can we make optimal use of these findings before all the conclusive laboratory and clinical ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member? Login Here

Meet the Author

  • Ronald Kostoff

    This person does not yet have a bio.

Published In

Share
May digest 2025 cover
May 2025, Issue 1

Study Confirms Safety of Genetically Modified T Cells

A long-term study of nearly 800 patients demonstrated a strong safety profile for T cells engineered with viral vectors.

View this Issue
iStock

TaqMan Probe & Assays: Unveil What's Possible Together

Thermo Fisher Logo
Meet Aunty and Tackle Protein Stability Questions in Research and Development

Meet Aunty and Tackle Protein Stability Questions in Research and Development

Unchained Labs
Detecting Residual Cell Line-Derived DNA with Droplet Digital PCR

Detecting Residual Cell Line-Derived DNA with Droplet Digital PCR

Bio-Rad
How technology makes PCR instruments easier to use.

Making Real-Time PCR More Straightforward

Thermo Fisher Logo

Products

fujirebio-square-logo

Fujirebio Receives Marketing Clearance for Lumipulse® G pTau 217/ β-Amyloid 1-42 Plasma Ratio In-Vitro Diagnostic Test

The Scientist Placeholder Image

Biotium Launches New Phalloidin Conjugates with Extended F-actin Staining Stability for Greater Imaging Flexibility

Leica Microsystems Logo

Latest AI software simplifies image analysis and speeds up insights for scientists

BioSkryb Genomics Logo

BioSkryb Genomics and Tecan introduce a single-cell multiomics workflow for sequencing-ready libraries in under ten hours