Nearly all scientists involved in basic biomedical research are familiar with the "Red Book" (Current Protocols in Molecular Biology)1 and Molecular Cloning: A Laboratory Manual.2 These well-known, time-tested books are still considered "bibles" in research laboratories, containing a wide range of basic techniques used by most life scientists. However, as scientific studies and experimental designs become more intricate and specialized, so do the techniques involved. As a result, detailed, "special-topic" protocol manuals are increasingly popular.

Any basic research laboratory using molecular biology techniques will benefit from having a copy on hand of the newly published Third Edition of Molecular Cloning: A Laboratory Manual, by Joe Sambrook and David Russell, from Cold Spring Harbor Laboratory Press.2 Originally published almost 20 years ago, the first two editions of this book have been staples of molecular biology with a proven reputation for accuracy and thoroughness. According...

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