Edited by: Karen Young Kreeger
M. Tewari, V.M. Dixit, "Fas- and tumor necrosis factor-induced apoptosis is inhibited by the poxvirus crmA gene product," Journal of Biological Chemistry, 270:3255-60, 1995. (Cited in more than 130 publications as of February 1997)
M. Tewari, L.T. Quan, K. O'Rourke, S. Desnoyers, Z. Zeng, D.R. Beidler, G.G. Poirier, G.S. Salvesen, V.M. Dixit, "Yama/CPP32ß, a mammalian homolog of CED-3, is a crmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase," Cell, 81:801-9, 1995. (Cited in more than 230 publications as of February 1997)
This pair of papers provides conclusive evidence for a group of proteins that are responsible for programmed cell death in mammals. The earlier paper, published in the Journal of Biological Chemistry (JBC), laid the groundwork for the later Cell paper. FINGERING THE CULPRIT: Studies by Muneesh Tewari, left, Vishva Dixit, and colleagues provided a definitive role for the ICE family of proteins in ...
