The paper
S. Tsai et al., “Reversal of autoimmunity by boosting memory-like autoregulatory T cells,” Immunity, 32:568-80, 2010. Free F1000 Evaluation
The finding
Autoimmune diseases such as multiple sclerosis develop over many years and result in chronic diseases that flare and subside. While trying to kill the cells responsible for the disease in mice, Pere Santamaria at the University of Calgary and colleagues activated a set of mysterious immune cells—and in the process, potentially offered both a new explanation for why inflammation comes and goes, and a new way to reverse the disease.
The surprise
The plan was to create nanoparticles that would only kill the T cells attacking healthy tissue in mice, leaving the normal immune system intact. “But it didn’t work,” says Santamaria—at least, not how he expected.
The clues
Rather than killing immune cells, Santamaria found that his nanoparticles activated a population of autoreactive CD8 T cells ...
