Courtesy of Genentech
Early Indications: My first and continued interest was human health and disease that subsequently evolved to the scientific mechanisms that underlie normal and aberrant immune function.
Mentors of Merit: I've had the luxury of multiple outstanding scientific mentors. The first was John Atkinson at Washington University in St. Louis, with whom I performed my thesis work. John is one who always meshed and identified the critical scientific questions that ultimately always had great relevance to medicine. I also had an outstanding postdoctoral mentor, Art Weiss, who helped me greatly to further increase the rigor and breadth of my scientific acumen.
Pivotal Paper: My work as a postdoctoral fellow in Art Weiss's University of California, San Francisco laboratory identified the ZAP-70 protein tyrosine kinase and suggested that the T-cell antigen receptor may activate downstream signaling functions through cooperation between different families of cytoplasmic protein tyrosine kinases (A.C. Chan...