Calcium-channel blockers and hypertension

NEW YORK, July 31 (Praxis Press) Cardiovascular outcomes have not been compared in hypertensive patients treated with calcium channel blockers and in patients treated with older drugs. Hansson and colleagues compared morbidity and mortality in 5,410 hypertensive patients randomized to diltiazem treatment and in 5,471 hypertensive patients randomized to treatment with diuretics, beta-blockers, or both. Both regimens effectively lowered systolic and diastolic blood pressure, although diuretics and beta-blockers more markedly lowered systolic blood pressure (P < 0.001). The combined primary endpoint of all stroke, myocardial infarction, and other cardiovascular death occurred with similar frequencies in both groups (relative risk, 1.00; P = 0.97). In another study, Brown and colleagues compared outcomes in 3,157 hypertensive patients randomized to treatment with long-acting nifedipine and in 3,164 hypertensive patients randomized to treatment with the diuretic combination co-amilozide. The combined primary outcome of cardiovascular death, myocardial infarction, heart failure, and stroke occurred with similar ...